Histidinol-phosphate aminotransferase
Details
- Name
- Histidinol-phosphate aminotransferase
- Synonyms
- 2.6.1.9
- Imidazole acetol-phosphate transaminase
- Gene Name
- hisC
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0011045|Histidinol-phosphate aminotransferase MNPLDLIAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDSPDEE LIEKILSYLDTDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPTYSCYRIFAKAVGAKF LEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVFEREEIERILKTGAFVALDEAYYEFH GESYVDFLKKYENLAVIRTFSKAFSLAAQRVGYVVASEKFIDAYNRVRLPFNVSYVSQMF AKVALDHREIFEERTKFIVEERERMKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHL RTKNVAVRSFREGVRITIGKREENDMILRELEVFK
- Number of residues
- 335
- Molecular Weight
- 39297.6
- Theoretical pI
- 5.15
- GO Classification
- Functionshistidinol-phosphate transaminase activity / L-phenylalanine / pyridoxal phosphate bindingProcesseshistidine biosynthetic process
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Not Available
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011046|Histidinol-phosphate aminotransferase (hisC) GTGAATCCTCTCGATTTGATTGCAAAGAGGGCGTATCCGTACGAAACCGAAAAGAGAGAC AAAACCTACCTTGCGCTGAATGAAAATCCGTTTCCCTTTCCAGAGGACCTCGTGGATGAA GTGTTTCGACGATTGAACAGCGACGCCCTGAGGATCTACTACGACTCCCCCGATGAAGAA TTAATAGAAAAGATACTCTCATACCTCGACACCGATTTTCTTTCGAAAAACAACGTCTCT GTGGGAAACGGAGCGGATGAGATCATCTACGTGATGATGCTCATGTTCGACCGTTCCGTT TTCTTTCCCCCGACCTACAGCTGCTACAGGATCTTTGCGAAGGCAGTTGGAGCGAAATTC CTGGAAGTGCCGCTCACGAAAGATCTGAGGATACCTGAGGTGAACGTGGGAGAAGGAGAC GTTGTTTTCATTCCGAACCCGAACAATCCAACGGGCCATGTCTTCGAAAGAGAGGAAATA GAAAGAATCCTGAAAACGGGTGCCTTCGTCGCGCTGGACGAAGCCTACTACGAATTCCAC GGAGAAAGTTATGTGGATTTTCTGAAGAAATACGAAAATCTCGCTGTGATCAGGACTTTC TCGAAAGCGTTTTCCCTGGCAGCGCAACGTGTCGGATACGTTGTGGCCTCGGAGAAGTTC ATTGACGCTTACAACAGGGTGAGACTTCCTTTCAACGTGAGCTACGTCTCCCAGATGTTC GCAAAGGTAGCTCTCGATCACAGAGAGATCTTTGAAGAAAGAACGAAGTTCATCGTGGAA GAACGCGAGAGGATGAAGAGTGCTCTCAGGGAAATGGGATACCGAATCACCGACTCCAGA GGAAACTTCGTGTTCGTATTCATGGAGAAGGAAGAAAAAGAAAGACTTCTCGAACACCTC CGGACGAAGAACGTCGCTGTTCGCAGTTTCAGGGAAGGTGTTAGAATCACTATCGGAAAA CGCGAAGAGAACGATATGATTCTGAGAGAACTGGAGGTGTTCAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X0D0 UniProtKB Entry Name HIS8_THEMA GenBank Protein ID 4981580 GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Fernandez FJ, Vega MC, Lehmann F, Sandmeier E, Gehring H, Christen P, Wilmanns M: Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase. J Biol Chem. 2004 May 14;279(20):21478-88. Epub 2004 Mar 8. [Article]