2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Details

Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Synonyms
  • 2.7.7.60
  • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
  • MCT
  • MEP cytidylyltransferase
Gene Name
ispD
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0011319|2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
MNVAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVV
EKRVFHEKVLGIVEGGDTRSQSVRSALEFLEKFSPSYVLVHDSARPFLRKKHVSEVLRRA
RETGAATLALKNSDALVRVENDRIEYIPRKGVYRILTPQAFSYEILKKAHENGGEWADDT
EPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIAREWERIP
Number of residues
222
Molecular Weight
25370.055
Theoretical pI
7.66
GO Classification
Functions
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Processes
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
General Function
2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase activity
Specific Function
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011320|2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
ATGAACGTAGCGATTCTCCTTGCAGCGGGAAAAGGTGAAAGAATGTCTGAAAACGTTCCA
AAACAGTTCCTCGAGATAGAGGGAAGGATGCTTTTCGAGTATCCGCTTTCCACGTTTTTG
AAAAGTGAAGCGATAGATGGTGTTGTGATAGTGACACGAAGAGAGTGGTTCGAAGTTGTA
GAGAAAAGAGTGTTCCACGAAAAAGTACTCGGAATTGTCGAGGGTGGAGATACACGAAGC
CAGAGTGTGAGAAGCGCCCTCGAATTTCTTGAAAAGTTCTCTCCCTCTTACGTTCTCGTA
CACGACTCAGCACGGCCGTTTCTGAGGAAGAAACACGTGTCGGAGGTTCTCAGAAGAGCC
CGCGAAACGGGAGCGGCAACCCTCGCGTTGAAGAATTCCGACGCGCTCGTAAGAGTTGAG
AACGACAGAATAGAATACATCCCAAGAAAAGGAGTGTACAGAATTCTTACACCGCAGGCT
TTTTCTTACGAGATTTTGAAAAAGGCCCATGAAAATGGTGGCGAATGGGCAGACGACACG
GAACCTGTTCAAAAGCTCGGAGTGAAAATAGCCTTGGTCGAGGGAGATCCTTTGTGTTTC
AAAGTGACGTTTAAAGAAGACCTGGAACTGGCGAGAATCATCGCCAGAGAATGGGAGAGG
ATACCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9X1B3
UniProtKB Entry NameISPD_THEMA
GenBank Protein ID4981955
GenBank Gene IDAE000512
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02431Cytidine-5'-TriphosphateexperimentalunknownDetails