2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Details
- Name
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Synonyms
- 23PGA-independent
- 5.4.2.12
- pgm
- Gene Name
- gpmI
- Organism
- Geobacillus stearothermophilus
- Amino acid sequence
>lcl|BSEQ0022418|2,3-bisphosphoglycerate-independent phosphoglycerate mutase MSKKPVALIILDGFALRDETYGNAVAQANKPNFDRYWNEYPHTTLKACGEAVGLPEGQMG NSEVGHLNIGAGRIVYQSLTRINIAIREGEFDRNETFLAAMNHVKQHGTSLHLFGLLSDG GVHSHIHHLYALLRLAAKEGVKRVYIHGFLDGRDVGPQTAPQYIKELQEKIKEYGVGEIA TLSGRYYSMDRDKRWDRVEKAYRAMVYGEGPTYRDPLECIEDSYKHGIYDEFVLPSVIVR EDGRPVATIQDNDAIIFYNFRPDRAIQISNTFTNEDFREFDRGPKHPKHLFFVCLTHFSE TVKGYVAFKPTNLDNTIGEVLSQHGLRQLRIAETEKYPHVTFFMSGGREEKFPGEDRILI NSPKVPTYDLKPEMSAYEVTDALLKEIEADKYDAIILNYANPDMVGHSGKLEPTIKAVEA VDECLGKVVDAILAKGGIAIITADHGNADEVLTPDGKPQTAHTTNPVPVIVTKKGIKLRD GGILGDLAPTMLDLLGLPQPKEMTGKSLIVK
- Number of residues
- 511
- Molecular Weight
- 57002.48
- Theoretical pI
- 6.39
- GO Classification
- Functions2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity / manganese ion bindingProcessesglucose catabolic process / glycolytic process / regulation of sporulation / sporulation resulting in formation of a cellular sporeComponentscytoplasm
- General Function
- Manganese ion binding
- Specific Function
- Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002442|1536 bp ATGAGTAAAAAACCGGTTGCGCTCATCATTTTAGACGGATTTGCGCTGCGCGACGAAACG TACGGCAATGCGGTCGCTCAGGCGAACAAACCGAACTTTGACCGCTATTGGAACGAATAC CCGCACACAACGCTCAAGGCGTGCGGCGAGGCGGTCGGGCTTCCGGAAGGGCAGATGGGC AACTCGGAAGTCGGCCATCTCAACATCGGCGCCGGGCGCATTGTGTACCAAAGCTTAACG CGAATCAACATTGCCATTCGCGAAGGCGAGTTTGACCGAAATGAAACGTTTTTGGCGGCG ATGAACCATGTGAAACAACACGGGACAAGTTTGCATTTGTTCGGCTTGCTTTCCGACGGC GGGGTGCACAGCCATATTCACCATTTGTACGCCCTCTTGCGCTTGGCGGCGAAAGAAGGC GTGAAGCGCGTGTACATCCACGGCTTTTTGGACGGCCGCGACGTCGGCCCACAAACAGCG CCGCAATACATTAAAGAACTGCAGGAAAAAATCAAGGAATATGGCGTCGGCGAAATCGCG ACGTTATCGGGCCGCTACTACTCGATGGACCGCGACAAGCGGTGGGACCGCGTCGAAAAG GCGTATCGGGCGATGGTGTACGGGGAAGGGCCGACGTACCGCGATCCGCTCGAGTGCATC GAGGACTCGTACAAACACGGCATTTACGACGAATTCGTCCTGCCGTCGGTCATCGTCCGC GAAGACGGCCGGCCGGTGGCGACGATTCAAGACAATGACGCGATTATCTTCTATAATTTC CGCCCTGACCGGGCGATCCAAATTTCAAACACGTTTACGAACGAAGATTTCCGCGAGTTT GACCGCGGCCCGAAACATCCGAAGCATTTGTTCTTTGTCTGCTTGACCCATTTCAGCGAA ACGGTGAAAGGGTACGTGGCGTTCAAGCCGACGAACTTGGACAACACGATCGGGGAAGTG CTGTCGCAGCACGGACTGCGCCAGCTGCGCATCGCCGAGACCGAAAAATATCCGCACGTG ACGTTTTTTATGAGCGGCGGCCGCGAAGAGAAATTTCCAGGCGAAGACCGGATTTTGATC AACTCGCCGAAAGTGCCGACGTATGACTTGAAGCCGGAAATGAGCGCCTATGAAGTGACC GATGCGCTGCTCAAGGAAATTGAAGCCGATAAGTACGATGCGATCATTTTGAACTACGCC AACCCGGATATGGTCGGCCATTCGGGCAAGCTCGAACCGACGATCAAGGCGGTGGAGGCA GTGGACGAATGCCTCGGCAAAGTCGTCGATGCCATTTTGGCCAAAGGCGGCATCGCCATC ATCACCGCCGACCACGGCAACGCCGATGAAGTATTGACGCCGGACGGCAAGCCGCAAACG GCTCATACGACGAATCCGGTGCCGGTCATCGTGACGAAAAAAGGCATCAAGCTTAGAGAC GGCGGCATCTTAGGCGATTTGGCGCCGACGATGCTCGATTTGCTCGGCTTGCCGCAGCCG AAAGAAATGACGGGGAAATCGTTGATTGTCAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X519 UniProtKB Entry Name GPMI_GEOSE GenBank Protein ID 4589058 GenBank Gene ID AF120091 - General References
- Chander M, Setlow P, Lamani E, Jedrzejas MJ: Structural studies on a 2,3-diphosphoglycerate independent phosphoglycerate mutase from Bacillus stearothermophilus. J Struct Biol. 1999 Jun 15;126(2):156-65. [Article]
- Jedrzejas MJ, Chander M, Setlow P, Krishnasamy G: Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilus. EMBO J. 2000 Apr 3;19(7):1419-31. [Article]
- Jedrzejas MJ, Chander M, Setlow P, Krishnasamy G: Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate. J Biol Chem. 2000 Jul 28;275(30):23146-53. [Article]
- Rigden DJ, Lamani E, Mello LV, Littlejohn JE, Jedrzejas MJ: Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling. J Mol Biol. 2003 May 9;328(4):909-20. [Article]