RuvB-like 2

Details

Name
RuvB-like 2
Synonyms
  • 3.6.4.12
  • 48 kDa TATA box-binding protein-interacting protein
  • 48 kDa TBP-interacting protein
  • 51 kDa erythrocyte cytosolic protein
  • ECP-51
  • INO80 complex subunit J
  • INO80J
  • Repressing pontin 52
  • Reptin 52
  • TAP54-beta
  • TIP48
  • TIP49B
  • TIP60-associated protein 54-beta
Gene Name
RUVBL2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049751|RuvB-like 2
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Number of residues
463
Molecular Weight
51156.08
Theoretical pI
Not Available
GO Classification
Functions
ADP binding / ATP binding / ATP-dependent 5'-3' DNA helicase activity / ATP-dependent DNA helicase activity / ATPase binding / chromatin DNA binding / DNA helicase activity / identical protein binding / protein homodimerization activity / RNA polymerase II core promoter sequence-specific DNA binding / RNA polymerase II distal enhancer sequence-specific DNA binding / TFIID-class transcription factor binding / unfolded protein binding
Processes
cellular response to estradiol stimulus / cellular response to UV / chromatin remodeling / DNA recombination / DNA repair / establishment of protein localization to chromatin / histone H2A acetylation / histone H4 acetylation / negative regulation of estrogen receptor binding / positive regulation of histone acetylation / positive regulation of telomerase RNA localization to Cajal body / positive regulation of transcription from RNA polymerase II promoter / protein folding / regulation of growth / transcription, DNA-templated / transcriptional activation by promoter-enhancer looping
Components
centrosome / cytosol / extracellular exosome / Ino80 complex / intracellular / intracellular ribonucleoprotein complex / membrane / MLL1 complex / NuA4 histone acetyltransferase complex / nuclear euchromatin / nuclear matrix / nucleoplasm / nucleus / R2TP complex / Swr1 complex
General Function
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.
Specific Function
Adp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus matrix
Gene sequence
>lcl|BSEQ0049752|RuvB-like 2 (RUVBL2)
ATGGCAACCGTTACAGCCACAACCAAAGTCCCGGAGATCCGTGATGTAACAAGGATTGAG
CGAATCGGTGCCCACTCCCACATCCGGGGACTGGGGCTGGACGATGCCTTGGAGCCTCGG
CAGGCTTCGCAAGGCATGGTGGGTCAGCTGGCGGCACGGCGGGCGGCTGGCGTGGTGCTG
GAGATGATCCGGGAAGGGAAGATTGCCGGTCGGGCAGTCCTTATTGCTGGCCAGCCGGGC
ACGGGGAAGACGGCCATCGCCATGGGCATGGCGCAGGCCCTGGGCCCTGACACGCCATTC
ACAGCCATCGCCGGCAGTGAAATCTTCTCCCTGGAGATGAGCAAGACCGAGGCGCTGACG
CAGGCCTTCCGGCGGTCCATCGGCGTTCGCATCAAGGAGGAGACGGAGATCATCGAAGGG
GAGGTGGTGGAGATCCAGATTGATCGACCAGCAACAGGGACGGGCTCCAAGGTGGGCAAA
CTGACCCTCAAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAG
TCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACGGGC
AAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCC
CAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCAC
ACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTC
TTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTG
GCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAG
GTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATG
GCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTAC
CAGAGCCCTCACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACC
CCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGTGCGAGGAAGAAGATGTG
GAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGC
TACGCCATCCAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAA
GTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACG
CAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATG
GACACCTCCTGA
Chromosome Location
19
Locus
19q13.33
External Identifiers
ResourceLink
UniProtKB IDQ9Y230
UniProtKB Entry NameRUVB2_HUMAN
HGNC IDHGNC:10475
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04216Quercetinexperimental, investigationalunknownDetails