Toll-like receptor 6
Details
- Name
- Toll-like receptor 6
- Synonyms
- 3.2.2.6
- Gene Name
- TLR6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052605|Toll-like receptor 6 MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV AFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA FNMKLTLVTENNDVKS
- Number of residues
- 796
- Molecular Weight
- 91878.845
- Theoretical pI
- Not Available
- GO Classification
- Functionsamyloid-beta binding / identical protein binding / lipopeptide binding / NAD(P)+ nucleosidase activity / NAD+ nucleotidase, cyclic ADP-ribose generating / protein heterodimerization activity / signaling receptor activity / signaling receptor binding / Toll-like receptor 2 binding / transmembrane signaling receptor activityProcessesactivation of NF-kappaB-inducing kinase activity / cell activation / cellular response to amyloid-beta / cellular response to bacterial lipopeptide / cellular response to diacyl bacterial lipopeptide / cellular response to oxidised low-density lipoprotein particle stimulus / defense response to bacterium / detection of diacyl bacterial lipopeptide / immune response / inflammatory response / innate immune response / microglial cell activation / MyD88-dependent toll-like receptor signaling pathway / negative regulation of interleukin-8 production / negative regulation of toll-like receptor 2 signaling pathway / nitric oxide metabolic process / positive regulation of cytokine production involved in inflammatory response / positive regulation of gene expression / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of interleukin-1 beta production / positive regulation of interleukin-6 production / positive regulation of JUN kinase activity / positive regulation of macrophage activation / positive regulation of NF-kappaB transcription factor activity / positive regulation of nitric oxide biosynthetic process / positive regulation of NLRP3 inflammasome complex assembly / positive regulation of oxidative stress-induced neuron death / positive regulation of reactive oxygen species biosynthetic process / signal transduction / toll-like receptor 6 signaling pathway / toll-like receptor signaling pathway / toll-like receptor TLR6 / TRIF-dependent toll-like receptor signaling pathwayComponentsGolgi apparatus / integral component of plasma membrane / membrane raft / phagocytic vesicle membrane / plasma membrane / receptor complex / Toll-like receptor 2-Toll-like receptor 6 protein complex
- General Function
- Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).
- Specific Function
- Amyloid-beta binding
- Pfam Domain Function
- Transmembrane Regions
- 587-607
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052606|Toll-like receptor 6 (TLR6) ATGACCAAAGACAAAGAACCTATTGTTAAAAGCTTCCATTTTGTTTGCCTTATGATCATA ATAGTTGGAACCAGAATCCAGTTCTCCGACGGAAATGAATTTGCAGTAGACAAGTCAAAA AGAGGTCTTATTCATGTTCCAAAAGACCTACCGCTGAAAACCAAAGTCTTAGATATGTCT CAGAACTACATCGCTGAGCTTCAGGTCTCTGACATGAGCTTTCTATCAGAGTTGACAGTT TTGAGACTTTCCCATAACAGAATCCAGCTACTTGATTTAAGTGTTTTCAAGTTCAACCAG GATTTAGAATATTTGGATTTATCTCATAATCAGTTGCAAAAGATATCCTGCCATCCTATT GTGAGTTTCAGGCATTTAGATCTCTCATTCAATGATTTCAAGGCCCTGCCCATCTGTAAG GAATTTGGCAACTTATCACAACTGAATTTCTTGGGATTGAGTGCTATGAAGCTGCAAAAA TTAGATTTGCTGCCAATTGCTCACTTGCATCTAAGTTATATCCTTCTGGATTTAAGAAAT TATTATATAAAAGAAAATGAGACAGAAAGTCTACAAATTCTGAATGCAAAAACCCTTCAC CTTGTTTTTCACCCAACTAGTTTATTCGCTATCCAAGTGAACATATCAGTTAATACTTTA GGGTGCTTACAACTGACTAATATTAAATTGAATGATGACAACTGTCAAGTTTTCATTAAA TTTTTATCAGAACTCACCAGAGGTTCAACCTTACTGAATTTTACCCTCAACCACATAGAA ACGACTTGGAAATGCCTGGTCAGAGTCTTTCAATTTCTTTGGCCCAAACCTGTGGAATAT CTCAATATTTACAATTTAACAATAATTGAAAGCATTCGTGAAGAAGATTTTACTTATTCT AAAACGACATTGAAAGCATTGACAATAGAACATATCACGAACCAAGTTTTTCTGTTTTCA CAGACAGCTTTGTACACCGTGTTTTCTGAGATGAACATTATGATGTTAACCATTTCAGAT ACACCTTTTATACACATGCTGTGTCCTCATGCACCAAGCACATTCAAGTTTTTGAACTTT ACCCAGAACGTTTTCACAGATAGTATTTTTGAAAAATGTTCCACGTTAGTTAAATTGGAG ACACTTATCTTACAAAAGAATGGATTAAAAGACCTTTTCAAAGTAGGTCTCATGACGAAG GATATGCCTTCTTTGGAAATACTGGATGTTAGCTGGAATTCTTTGGAATCTGGTAGACAT AAAGAAAACTGCACTTGGGTTGAGAGTATAGTGGTGTTAAATTTGTCTTCAAATATGCTT ACTGACTCTGTTTTCAGATGTTTACCTCCCAGGATCAAGGTACTTGATCTTCACAGCAAT AAAATAAAGAGCGTTCCTAAACAAGTCGTAAAACTGGAAGCTTTGCAAGAACTCAATGTT GCTTTCAATTCTTTAACTGACCTTCCTGGATGTGGCAGCTTTAGCAGCCTTTCTGTATTG ATCATTGATCACAATTCAGTTTCCCACCCATCGGCTGATTTCTTCCAGAGCTGCCAGAAG ATGAGGTCAATAAAAGCAGGGGACAATCCATTCCAATGTACCTGTGAGCTAAGAGAATTT GTCAAAAATATAGACCAAGTATCAAGTGAAGTGTTAGAGGGCTGGCCTGATTCTTATAAG TGTGACTACCCAGAAAGTTATAGAGGAAGCCCACTAAAGGACTTTCACATGTCTGAATTA TCCTGCAACATAACTCTGCTGATCGTCACCATCGGTGCCACCATGCTGGTGTTGGCTGTG ACTGTGACCTCCCTCTGCATCTACTTGGATCTGCCCTGGTATCTCAGGATGGTGTGCCAG TGGACCCAGACTCGGCGCAGGGCCAGGAACATACCCTTAGAAGAACTCCAAAGAAACCTC CAGTTTCATGCTTTTATTTCATATAGTGAACATGATTCTGCCTGGGTGAAAAGTGAATTG GTACCTTACCTAGAAAAAGAAGATATACAGATTTGTCTTCATGAGAGAAACTTTGTCCCT GGCAAGAGCATTGTGGAAAATATCATCAACTGCATTGAGAAGAGTTACAAGTCCATCTTT GTTTTGTCTCCCAACTTTGTCCAGAGTGAGTGGTGCCATTACGAACTCTATTTTGCCCAT CACAATCTCTTTCATGAAGGATCTAATAACTTAATCCTCATCTTACTGGAACCCATTCCA CAGAACAGCATTCCCAACAAGTACCACAAGCTGAAGGCTCTCATGACGCAGCGGACTTAT TTGCAGTGGCCCAAGGAGAAAAGCAAACGTGGGCTCTTTTGGGCTAACATTAGAGCCGCT TTTAATATGAAATTAACACTAGTCACTGAAAACAATGATGTGAAATCTTAA
- Chromosome Location
- 4
- Locus
- 4p14
- External Identifiers
Resource Link UniProtKB ID Q9Y2C9 UniProtKB Entry Name TLR6_HUMAN HGNC ID HGNC:16711 - General References
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