Serine/threonine-protein kinase 38-like

Details

Name
Serine/threonine-protein kinase 38-like
Synonyms
  • 2.7.11.1
  • KIAA0965
  • NDR2
  • NDR2 protein kinase
  • Nuclear Dbf2-related kinase 2
Gene Name
STK38L
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051658|Serine/threonine-protein kinase 38-like
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD
EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI
LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM
KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK
AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY
NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR
FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL
QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL
Number of residues
464
Molecular Weight
54002.425
Theoretical pI
Not Available
GO Classification
Functions
actin binding / ATP binding / magnesium ion binding / protein serine/threonine kinase activity
Processes
intracellular signal transduction / peptidyl-serine phosphorylation / protein phosphorylation / regulation of cellular component organization
Components
actin cytoskeleton / cytoplasm / cytosol / membrane
General Function
Involved in the regulation of structural processes in differentiating and mature neuronal cells.
Specific Function
Actin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051659|Serine/threonine-protein kinase 38-like (STK38L)
ATGGCAATGACGGCAGGGACTACAACAACCTTTCCTATGAGCAACCATACCCGGGAAAGA
GTGACTGTAGCCAAGCTCACATTGGAGAATTTTTATAGCAACCTAATTTTACAGCATGAA
GAGAGAGAAACCAGGCAGAAGAAATTAGAAGTGGCCATGGAAGAAGAAGGATTAGCAGAT
GAAGAGAAAAAGTTACGTCGATCACAACACGCTCGCAAAGAAACAGAGTTCTTACGGCTC
AAAAGGACCAGACTTGGCTTGGATGACTTTGAGTCTCTGAAAGTTATAGGAAGAGGAGCT
TTTGGAGAGGTGCGGTTGGTCCAGAAGAAAGATACAGGCCATATCTATGCAATGAAGATA
TTGAGAAAGTCTGATATGCTTGAAAAAGAGCAGGTGGCCCATATCCGAGCAGAAAGAGAT
ATTTTGGTAGAAGCAGATGGTGCCTGGGTGGTGAAGATGTTTTACAGTTTTCAGGATAAG
AGGAATCTTTATCTAATCATGGAATTTCTCCCTGGAGGTGACATGATGACATTGCTAATG
AAGAAAGACACCTTGACAGAAGAGGAAACACAGTTCTACATTTCAGAGACTGTTCTGGCA
ATAGATGCGATCCACCAGTTGGGTTTCATCCATCGGGATATTAAGCCAGACAACCTTTTA
TTGGATGCCAAGGGTCATGTAAAATTATCTGATTTTGGTTTATGTACGGGATTAAAGAAA
GCTCACAGGACTGAATTTTATAGAAATCTCACACACAACCCACCAAGTGACTTCTCATTT
CAGAACATGAACTCAAAGAGGAAAGCAGAAACTTGGAAGAAGAACAGGAGACAACTGGCA
TATTCCACAGTTGGGACACCAGATTACATTGCTCCAGAAGTATTCATGCAGACTGGTTAC
AACAAATTGTGTGACTGGTGGTCTTTGGGAGTGATTATGTATGAAATGCTAATAGGATAT
CCACCTTTCTGCTCTGAAACACCTCAAGAAACGTACAGAAAAGTGATGAACTGGAAAGAA
ACTCTGGTATTTCCTCCAGAGGTACCTATATCTGAGAAAGCCAAGGACTTAATTCTCAGA
TTTTGTATTGATTCTGAAAACAGAATTGGAAATAGTGGAGTAGAAGAAATAAAAGGTCAT
CCCTTTTTTGAAGGTGTCGACTGGGAGCACATAAGGGAAAGGCCAGCAGCAATCCCTATA
GAAATCAAAAGCATTGATGATACTTCAAATTTTGATGACTTCCCTGAATCTGATATTTTA
CAACCAGTGCCAAATACCACAGAACCGGACTACAAATCCAAAGACTGGGTTTTTCTCAAT
TATACCTATAAAAGGTTTGAAGGGTTGACTCAACGTGGCTCTATCCCCACCTACATGAAA
GCTGGGAAGTTATGA
Chromosome Location
12
Locus
12p11.23
External Identifiers
ResourceLink
UniProtKB IDQ9Y2H1
UniProtKB Entry NameST38L_HUMAN
HGNC IDHGNC:17848
General References
  1. Stegert MR, Tamaskovic R, Bichsel SJ, Hergovich A, Hemmings BA: Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. J Biol Chem. 2004 May 28;279(22):23806-12. Epub 2004 Mar 22. [Article]
  2. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Feb 26;6(1):63-70. [Article]
  3. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
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  7. Devroe E, Erdjument-Bromage H, Tempst P, Silver PA: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem. 2004 Jun 4;279(23):24444-51. Epub 2004 Apr 2. [Article]
  8. Stegert MR, Hergovich A, Tamaskovic R, Bichsel SJ, Hemmings BA: Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol Cell Biol. 2005 Dec;25(24):11019-29. [Article]
  9. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails