V-type proton ATPase 116 kDa subunit a isoform 2

Details

Name

V-type proton ATPase 116 kDa subunit a isoform 2

Synonyms

• Lysosomal H(+)-transporting ATPase V0 subunit a2
• TJ6
• V-ATPase 116 kDa isoform a2
• Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2

Gene Name

ATP6V0A2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052445|V-type proton ATPase 116 kDa subunit a isoform 2
MGSLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEE
LERILVYLVQEINRADIPLPEGEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRK
NLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFPSLESDSLLDYSCMQRLGAKLGFVSGLI
NQGKVEAFEKMLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKK
ICDCYHCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVI
QVKKMKAIYHMLNMCSFDVTNKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNII
PTKETPPTRIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFV
MFLFALLLVLNENHPRLNQSQEIMRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFG
SGWNVSAMYSSSHPPAEHKKMVLWNDSVVRHNSILQLDPSIPGVFRGPYPLGIDPIWNLA
TNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRKKFNIYLVSIPELLFMLCIFGY
LIFMIFYKWLVFSAETSRVAPSILIEFINMFLFPASKTSGLYTGQEYVQRVLLVVTALSV
PVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDSEEEVSLLGSQDIEEGNHQVEDGCRE
MACEEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLR
VDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPF
SFSLLSSKFNNDDSVA

Number of residues

856

Molecular Weight

98081.475

Theoretical pI

Not Available

GO Classification

Functions

ATPase binding / proton-transporting ATPase activity, rotational mechanism

Processes

cellular iron ion homeostasis / cellular response to increased oxygen levels / immune response / insulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / regulation of macroautophagy / transferrin transport / vacuolar acidification

Components

acrosomal vesicle / cell / endosome membrane / integral component of membrane / lysosomal membrane / perinuclear region of cytoplasm / phagocytic vesicle membrane / plasma membrane / vacuolar proton-transporting V-type ATPase complex / vacuolar proton-transporting V-type ATPase, V0 domain

General Function

Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

Specific Function

Atpase binding

Pfam Domain Function

• V_ATPase_I (PF01496)

Transmembrane Regions

394-412 415-431 446-475 550-569 588-608 652-671 740-764 786-824

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052446|V-type proton ATPase 116 kDa subunit a isoform 2 (ATP6V0A2)
ATGGGGTCCCTGTTCCGGAGCGAGACCATGTGCCTGGCGCAGCTCTTCCTGCAGTCGGGC
ACGGCCTACGAGTGCCTCAGCGCCCTGGGCGAGAAAGGCCTGGTCCAGTTCCGAGACCTC
AACCAGAACGTAAGTTCTTTCCAAAGAAAATTTGTTGGTGAGGTGAAGAGGTGTGAAGAG
CTAGAGCGAATATTGGTGTATTTGGTACAGGAAATTAATAGAGCTGATATTCCCCTTCCT
GAAGGAGAGGCCAGCCCTCCTGCGCCACCCCTGAAACAGGTTCTAGAAATGCAGGAGCAG
TTGCAGAAGCTCGAGGTTGAACTGAGAGAAGTCACTAAGAACAAGGAGAAACTGAGGAAA
AACTTGCTGGAACTGATAGAGTACACTCACATGCTGAGAGTGACAAAGACCTTTGTGAAA
CGCAATGTTGAGTTTGAACCCACTTATGAAGAATTCCCTTCCTTAGAGAGTGATTCTTTG
TTGGATTACAGCTGTATGCAGAGGCTGGGAGCAAAACTGGGATTTGTGTCTGGCCTAATT
AACCAAGGAAAAGTGGAAGCATTTGAAAAAATGTTGTGGAGAGTCTGCAAAGGGTACACC
ATCGTGTCCTATGCAGAACTGGATGAATCCCTTGAAGACCCTGAAACAGGGGAAGTCATA
AAATGGTATGTCTTTTTAATATCCTTTTGGGGAGAGCAGATTGGCCACAAGGTTAAGAAG
ATATGTGATTGCTACCACTGCCACGTGTACCCCTATCCAAACACAGCCGAGGAGCGGAGG
GAGATCCAGGAGGGGCTGAACACCCGCATCCAGGATCTCTACACTGTACTGCACAAAACC
GAGGACTATTTGAGGCAAGTGCTATGTAAAGCCGCCGAGTCTGTCTACAGCCGTGTGATC
CAGGTGAAGAAAATGAAGGCCATCTATCACATGCTGAACATGTGCAGCTTTGACGTGACC
AACAAGTGCCTCATTGCTGAGGTCTGGTGTCCCGAGGCGGATCTGCAGGACCTGCGCCGG
GCACTGGAGGAGGGCTCGAGAGAGAGTGGTGCTACAATCCCCTCATTCATGAATATAATC
CCCACAAAAGAAACACCCCCCACTCGGATCCGCACCAACAAATTCACCGAGGGATTTCAG
AACATCGTGGATGCTTATGGAGTCGGAAGCTACAGAGAAGTCAATCCAGCTCTCTTTACC
ATCATCACCTTCCCGTTTTTATTTGCTGTGATGTTTGGAGACTTCGGACATGGCTTTGTG
ATGTTTTTATTTGCCCTCTTGTTGGTGTTAAATGAAAATCATCCCAGACTAAATCAGTCA
CAAGAGATCATGAGGATGTTTTTTAATGGCCGGTACATCCTCCTGCTGATGGGGCTGTTC
TCAGTGTACACTGGCCTCATCTACAACGACTGCTTTTCAAAGTCAGTCAACCTGTTCGGC
TCTGGGTGGAACGTGTCGGCCATGTACAGCTCCAGCCACCCACCCGCAGAGCATAAGAAG
ATGGTGCTTTGGAATGACAGCGTCGTTAGACACAACAGCATTTTGCAGCTGGATCCAAGC
ATTCCTGGAGTGTTCCGAGGCCCTTATCCCCTTGGCATTGATCCTATTTGGAACTTGGCC
ACAAATCGCCTCACTTTTCTAAACTCTTTCAAAATGAAAATGTCCGTGATTTTAGGAATC
ATTCATATGACTTTTGGAGTCATTCTGGGAATATTTAACCACTTGCACTTCAGGAAGAAG
TTCAACATTTACCTGGTTTCCATCCCGGAACTTCTCTTCATGCTCTGTATCTTTGGATAC
CTTATATTTATGATTTTCTACAAGTGGCTGGTTTTTTCAGCAGAAACCTCCAGAGTTGCT
CCCAGCATTCTGATTGAATTTATTAACATGTTTTTATTCCCAGCCAGTAAAACAAGTGGC
CTTTACACAGGGCAGGAGTATGTCCAGAGAGTGCTGCTGGTTGTCACAGCATTGTCTGTC
CCTGTCCTCTTCTTGGGAAAGCCACTGTTTTTGTTGTGGCTTCACAATGGGCGTAGTTGC
TTCGGGGTGAACCGGAGTGGCTACACACTTATAAGGAAAGATAGTGAGGAAGAAGTTTCA
TTGCTGGGAAGCCAAGATATAGAAGAGGGAAATCACCAGGTGGAAGATGGATGTAGAGAA
ATGGCGTGTGAAGAGTTTAATTTTGGAGAAATATTAATGACCCAAGTAATCCATTCCATC
GAGTACTGTCTGGGATGCATCTCCAACACCGCCTCCTACCTGAGGCTCTGGGCGCTTAGC
CTGGCTCACGCACAGTTGTCTGATGTCCTGTGGGCCATGCTGATGCGCGTGGGCCTCCGC
GTTGACACCACCTATGGCGTCTTGCTACTGCTCCCGGTTATCGCGCTCTTTGCAGTTTTG
ACCATTTTCATCCTTCTGATCATGGAAGGGCTTTCTGCGTTTCTTCACGCCATACGCCTC
CACTGGGTAGAATTTCAGAACAAATTCTACGTTGGTGCAGGCACCAAATTTGTTCCTTTC
TCATTCAGTCTACTTTCATCAAAGTTCAATAACGACGACAGTGTGGCATGA

Chromosome Location

12

Locus

12q24.31

External Identifiers

Resource	Link
UniProtKB ID	Q9Y487
UniProtKB Entry Name	VPP2_HUMAN
HGNC ID	HGNC:18481

General References

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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01133	Tiludronic acid	approved, investigational, vet_approved	unknown	inhibitor	Details