Trafficking protein particle complex subunit 1
Details
- Name
- Trafficking protein particle complex subunit 1
- Synonyms
- BET5
- BET5 homolog
- Multiple myeloma protein 2
- MUM-2
- MUM2
- Gene Name
- TRAPPC1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012981|Trafficking protein particle complex subunit 1 MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDG FLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQT VQSELFRSRLDSYVRSLPFFSARAG
- Number of residues
- 145
- Molecular Weight
- 16831.44
- Theoretical pI
- 9.47
- GO Classification
- FunctionsRab guanyl-nucleotide exchange factor activityProcessescellular protein metabolic process / COPII vesicle coating / ER to Golgi vesicle-mediated transport / membrane organization / positive regulation of GTPase activity / post-translational protein modification / protein N-linked glycosylation via asparagineComponentscis-Golgi network / cytosol / endoplasmic reticulum / Golgi membrane / TRAPP complex
- General Function
- Rab guanyl-nucleotide exchange factor activity
- Specific Function
- May play a role in vesicular transport from endoplasmic reticulum to Golgi.
- Pfam Domain Function
- Sybindin (PF04099)
- Transmembrane Regions
- Not Available
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0012982|Trafficking protein particle complex subunit 1 (TRAPPC1) ATGACTGTCCACAACCTGTACCTGTTTGACCGGAATGGAGTGTGTCTGCACTACAGCGAA TGGCACCGCAAGAAGCAAGCAGGGATTCCCAAGGAGGAGGAGTATAAGCTGATGTACGGG ATGCTCTTCTCTATCCGCTCGTTTGTCAGCAAGATGTCCCCGCTAGACATGAAGGATGGC TTCCTGGCCTTCCAAACTAGCCGTTACAAACTCCATTACTACGAGACGCCCACTGGGATC AAAGTTGTCATGAATACTGACTTGGGCGTGGGACCCATCCGAGATGTGCTGCACCACATC TACAGTGCGCTGTATGTGGAGCTGGTGGTGAAGAATCCCCTGTGCCCGCTGGGCCAAACT GTGCAAAGTGAGCTCTTTCGCTCCCGACTGGACTCCTATGTTCGCTCTCTGCCCTTCTTC TCCGCCCGGGCTGGCTGA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID Q9Y5R8 UniProtKB Entry Name TPPC1_HUMAN GenBank Protein ID 21619196 GenBank Gene ID BC032717 HGNC ID HGNC:19894 - General References
- Chiari R, Foury F, De Plaen E, Baurain JF, Thonnard J, Coulie PG: Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. Cancer Res. 1999 Nov 15;59(22):5785-92. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G: Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]