UbiA prenyltransferase domain-containing protein 1
Details
- Name
- UbiA prenyltransferase domain-containing protein 1
- Synonyms
- 2.5.1.-
- TERE1
- Transitional epithelial response protein 1
- Gene Name
- UBIAD1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052573|UbiA prenyltransferase domain-containing protein 1 MAASQVLGEKINILSGETVKAGDRDPLGNDCPEQDRLPQRSWRQKCASYVLALRPWSFSA SLTPVALGSALAYRSHGVLDPRLLVGCAVAVLAVHGAGNLVNTYYDFSKGIDHKKSDDRT LVDRILEPQDVVRFGVFLYTLGCVCAACLYYLSPLKLEHLALIYFGGLSGSFLYTGGIGF KYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESD REAGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQF RSQAFNKLPQRTAKLNLLLGLFYVFGIILAPAGSLPKI
- Number of residues
- 338
- Molecular Weight
- 36830.745
- Theoretical pI
- Not Available
- GO Classification
- Functionsantioxidant activity / prenyltransferase activityProcessesmenaquinone biosynthetic process / ubiquinone biosynthetic process / ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate / vitamin K biosynthetic process / vitamin K metabolic processComponentscytoplasm / endoplasmic reticulum / endoplasmic reticulum membrane / integral component of Golgi membrane / membrane / mitochondrial membrane / nucleus
- General Function
- Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
- Specific Function
- Antioxidant activity
- Pfam Domain Function
- UbiA (PF01040)
- Transmembrane Regions
- 83-103 134-154 160-180 188-208 209-229 245-267 277-297 315-335
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0052574|UbiA prenyltransferase domain-containing protein 1 (UBIAD1) ATGGCGGCCTCTCAGGTCCTGGGGGAGAAGATTAACATCCTGTCGGGAGAGACTGTCAAA GCTGGGGACAGGGACCCGCTGGGGAACGACTGTCCCGAGCAAGATAGGCTCCCCCAGCGC TCCTGGAGGCAGAAGTGTGCCTCCTACGTGTTGGCCCTGAGGCCCTGGAGCTTCAGTGCC TCACTCACACCGGTGGCCCTGGGCAGTGCCCTTGCCTACAGATCCCACGGTGTCCTGGAT CCCAGGCTCTTGGTGGGTTGTGCCGTGGCTGTCCTGGCTGTGCACGGGGCCGGTAATTTG GTCAACACTTACTATGACTTTTCCAAGGGCATTGACCACAAAAAGAGTGATGACAGGACA CTTGTGGACCGAATCTTGGAGCCGCAGGATGTCGTCCGGTTCGGAGTCTTCCTCTACACG TTGGGCTGCGTCTGTGCCGCTTGCCTCTACTACCTGTCCCCTCTGAAACTGGAGCACTTG GCTCTTATCTACTTTGGAGGCCTGTCTGGCTCCTTTCTCTACACAGGAGGAATTGGATTC AAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTGATG TTCGCCTACGCCATCCAGGTGGGGTCCCTGGCCATCTTCCCACTGGTCTATGCCATCCCC CTCGCCCTCAGCACCGAGGCCATTCTCCATTCCAACAACACCAGGGACATGGAGTCCGAC CGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATTCTC TACAACACACTGCTCTTCCTGCCCTACCTGGTCTTCAGCATCCTGGCCACACACTGCACC ATCAGCCTGGCACTCCCCCTGCTTACCATTCCCATGGCCTTCTCCCTTGAGAGACAGTTT CGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTGGGA CTTTTCTATGTCTTTGGCATCATTCTGGCACCAGCAGGCAGTCTGCCCAAAATTTAA
- Chromosome Location
- 1
- Locus
- 1p36.22
- External Identifiers
Resource Link UniProtKB ID Q9Y5Z9 UniProtKB Entry Name UBIA1_HUMAN HGNC ID HGNC:30791 - General References
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