Solute carrier family 22 member 7
Details
- Name
- Solute carrier family 22 member 7
- Synonyms
- hOAT2
- NLT
- Novel liver transporter
- OAT2
- Organic anion transporter 2
- Gene Name
- SLC22A7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007007|Solute carrier family 22 member 7 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE MPMKQVQN
- Number of residues
- 548
- Molecular Weight
- 60025.025
- Theoretical pI
- 7.03
- GO Classification
- Functionssodium-independent organic anion transmembrane transporter activityProcessesanion transmembrane transport / organic anion transport / transmembrane transportComponentsbasolateral plasma membrane / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 21-41 146-166 180-200 204-224 234-254 259-279 346-366 376-397 404-423 432-452 466-486 493-513
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0012535|Solute carrier family 22 member 7 (SLC22A7) ATGGGCTTTGAGGAGCTGCTGGAGCAGGTGGGCGGCTTTGGGCCCTTCCAACTGCGGAAT GTGGCACTGCTGGCCCTGCCCCGAGTGCTGCTACCACTGCACTTCCTCCTGCCCATCTTC CTGGCTGCCGTGCCTGCCCACCGATGTGCCCTGCCGGGTGCCCCTGCCAACTTCAGCCAT CAGGATGTGTGGCTGGAGGCCCATCTTCCCCGGGAGCCTGATGGCACGCTCAGCTCCTGC CTCCGCTTTGCCTATCCCCAGGCTCTCCCCAACACCACGTTGGGGGAAGAAAGGCAGAGC CGTGGGGAGCTGGAGGATGAACCTGCCACAGTGCCCTGCTCTCAGGGCTGGGAGTACGAC CACTCAGAATTCTCCTCTACCATTGCAACTGAGTGGGATCTGGTGTGTGAGCAGAAAGGT CTGAACAGAGCTGCGTCCACTTTCTTCTTCGCCGGTGTGCTGGTGGGGGCTGTGGCCTTT GGATATCTGTCCGACAGGTTTGGGCGGCGGCGTCTGCTGCTGGTAGCCTACGTGAGTACC CTGGTGCTGGGCCTGGCATCTGCAGCCTCCGTCAGCTATGTAATGTTTGCCATCACCCGC ACCCTTACTGGCTCAGCCCTGGCTGGTTTTACCATCATCGTGATGCCACTGGAGCTGGAG TGGCTGGATGTGGAGCACCGCACCGTGGCTGGAGTCCTGAGCAGCACCTTCTGGACAGGG GGCGTGATGCTGCTGGCACTGGTTGGGTACCTGATACGGGACTGGCGATGGCTTCTGCTA GCTGTCACCCTGCCTTGTGCCCCAGGCATCCTCAGCCTCTGGTGGGTGCCTGAGTCTGCA CGCTGGCTTCTGACCCAAGGCCATGTGAAAGAGGCCCACAGGTACTTGCTCCACTGTGCC AGGCTCAATGGGCGGCCAGTGTGTGAGGACAGCTTCAGCCAGGAGGCTGTGAGCAAAGTG GCCGCCGGGGAACGGGTGGTCCGAAGACCTTCATACCTAGACCTGTTCCGCACACCACGG CTCCGACACATCTCACTGTGCTGCGTGGTGGTGTGGTTCGGAGTGAACTTCTCCTATTAC GGCCTGAGTCTGGATGTGTCGGGGCTGGGGCTGAACGTGTACCAGACACAGCTGTTGTTC GGGGCTGTGGAACTGCCCTCCAAGCTGCTGGTCTACTTGTCGGTGCGCTACGCAGGACGC CGCCTCACGCAAGCCGGGACACTGCTGGGCACGGCCCTGGCGTTCGGCACTAGACTGCTA GTGTCCTCCGATATGAAGTCCTGGAGCACTGTCCTGGCAGTGATGGGGAAAGCTTTTTCT GAAGCTGCCTTCACCACTGCCTACCTGTTCACTTCAGAGTTGTACCCTACGGTGCTCAGA CAGACAGGGATGGGGCTGACTGCACTGGTGGGCCGGCTGGGGGGCTCTTTGGCCCCACTG GCGGCCTTGCTGGATGGAGTGTGGCTGTCACTGCCCAAGCTTACTTATGGGGGGATCGCC CTGCTGGCTGCCGGCACCGCCCTCCTGCTGCCAGAGACGAGGCAGGCACAGCTGCCAGAG ACCATCCAGGACGTGGAGAGAAAGAGTGCCCCAACCAGTCTTCAGGAGGAAGAGATGCCC ATGAAGCAGGTCCAGAACTAA
- Chromosome Location
- 6
- Locus
- 6p21.2-p21.1
- External Identifiers
Resource Link UniProtKB ID Q9Y694 UniProtKB Entry Name S22A7_HUMAN GenBank Protein ID 5001689 GenBank Gene ID AF097518 HGNC ID HGNC:10971 - General References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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- Sun W, Wu RR, van Poelje PD, Erion MD: Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun. 2001 May 4;283(2):417-22. [Article]
- Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Kobayashi Y, Yamamoto T, Sekine T, Cha SH, Niwa T, Endou H: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. [Article]
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- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00624 Testosterone approved, investigational unknown inhibitor Details DB00759 Tetracycline approved, vet_approved, withdrawn unknown inhibitor Details DB00595 Oxytetracycline approved, investigational, vet_approved unknown substrateinhibitor Details DB01017 Minocycline approved, investigational unknown inhibitor Details DB01004 Ganciclovir approved, investigational unknown inhibitor Details DB00917 Dinoprostone approved unknown substrateinhibitor Details DB01032 Probenecid approved, investigational unknown inhibitor Details DB00456 Cefalotin approved, investigational, vet_approved unknown inhibitor Details DB00493 Cefotaxime approved unknown inhibitor Details DB01329 Cefoperazone approved, investigational unknown inhibitor Details DB01326 Cefamandole approved, experimental unknown inhibitor Details DB00175 Pravastatin approved no substrate Details DB00277 Theophylline approved unknown inhibitor Details DB01211 Clarithromycin approved unknown inhibitor Details DB00584 Enalapril approved, vet_approved unknown inhibitor Details DB00501 Cimetidine approved, investigational unknown substrateinhibitor Details DB01045 Rifampicin approved unknown inhibitor Details DB01009 Ketoprofen approved, vet_approved unknown inhibitor Details DB02659 Cholic Acid approved unknown inhibitor Details DB00887 Bumetanide approved unknown inhibitor Details DB01016 Glyburide approved unknown inhibitor Details DB00345 Aminohippuric acid approved, investigational unknown substrate Details DB00563 Methotrexate approved unknown substrate Details DB02527 Cyclic adenosine monophosphate experimental unknown substrate Details DB00313 Valproic acid approved, investigational unknown substrate Details DB00936 Salicylic acid approved, investigational, vet_approved unknown substrate Details DB03553 Glutaric Acid experimental unknown substrate Details DB00437 Allopurinol approved unknown substrate Details DB00943 Zalcitabine approved, investigational unknown substrate Details DB00328 Indomethacin approved, investigational unknown substrate Details DB01303 Oxtriphylline approved unknown inhibitor Details DB00495 Zidovudine approved unknown Details DB01160 Dinoprost tromethamine approved, vet_approved unknown Details DB00544 Fluorouracil approved unknown substrate Details DB01248 Docetaxel approved, investigational unknown substrate Details DB00493 Cefotaxime approved unknown Details DB13943 Testosterone cypionate approved unknown inducer Details DB13944 Testosterone enanthate approved unknown inducer Details DB13946 Testosterone undecanoate approved, investigational unknown inducer Details DB09327 Tegafur-uracil approved, investigational no substrate Details