Tumor necrosis factor receptor superfamily member 11A

Details

Name
Tumor necrosis factor receptor superfamily member 11A
Synonyms
  • ODFR
  • Osteoclast differentiation factor receptor
  • RANK
  • Receptor activator of NF-KB
Gene Name
TNFRSF11A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006732|Tumor necrosis factor receptor superfamily member 11A
MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC
TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW
SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK
RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK
ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC
YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL
LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN
YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP
EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM
NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE
PEKASRPVQEQGGAKA
Number of residues
616
Molecular Weight
66033.365
Theoretical pI
5.0
GO Classification
Functions
cytokine binding / metal ion binding / receptor activity / transmembrane signaling receptor activity / tumor necrosis factor-activated receptor activity
Processes
adaptive immune response / apoptotic signaling pathway / cell-cell signaling / circadian temperature homeostasis / inflammatory response / lymph node development / mammary gland alveolus development / monocyte chemotaxis / ossification / osteoclast differentiation / positive regulation of cell proliferation / positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling / positive regulation of fever generation by positive regulation of prostaglandin secretion / positive regulation of JUN kinase activity / positive regulation of NF-kappaB transcription factor activity / positive regulation of sequence-specific DNA binding transcription factor activity / regulation of apoptotic process / response to cytokine / response to interleukin-1 / response to lipopolysaccharide / response to radiation / response to tumor necrosis factor / signal transduction / TNFSF11-mediated signaling pathway / tumor necrosis factor-mediated signaling pathway
Components
external side of plasma membrane / integral component of plasma membrane / plasma membrane
General Function
Tumor necrosis factor-activated receptor activity
Specific Function
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Pfam Domain Function
Transmembrane Regions
213-233
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012417|Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
ATGGCCCCGCGCGCCCGGCGGCGCCGCCCGCTGTTCGCGCTGCTGCTGCTCTGCGCGCTG
CTCGCCCGGCTGCAGGTGGCTTTGCAGATCGCTCCTCCATGTACCAGTGAGAAGCATTAT
GAGCATCTGGGACGGTGCTGTAACAAATGTGAACCAGGAAAGTACATGTCTTCTAAATGC
ACTACTACCTCTGACAGTGTATGTCTGCCCTGTGGCCCGGATGAATACTTGGATAGCTGG
AATGAAGAAGATAAATGCTTGCTGCATAAAGTTTGTGATACAGGCAAGGCCCTGGTGGCC
GTGGTCGCCGGCAACAGCACGACCCCCCGGCGCTGCGCGTGCACGGCTGGGTACCACTGG
AGCCAGGACTGCGAGTGCTGCCGCCGCAACACCGAGTGCGCGCCGGGCCTGGGCGCCCAG
CACCCGTTGCAGCTCAACAAGGACACAGTGTGCAAACCTTGCCTTGCAGGCTACTTCTCT
GATGCCTTTTCCTCCACGGACAAATGCAGACCCTGGACCAACTGTACCTTCCTTGGAAAG
AGAGTAGAACATCATGGGACAGAGAAATCCGATGCGGTTTGCAGTTCTTCTCTGCCAGCT
AGAAAACCACCAAATGAACCCCATGTTTACTTGCCCGGTTTAATAATTCTGCTTCTCTTC
GCGTCTGTGGCCCTGGTGGCTGCCATCATCTTTGGCGTTTGCTATAGGAAAAAAGGGAAA
GCACTCACAGCTAATTTGTGGCACTGGATCAATGAGGCTTGTGGCCGCCTAAGTGGAGAT
AAGGAAATGTGA
Chromosome Location
18
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9Y6Q6
UniProtKB Entry NameTNR11_HUMAN
GenBank Gene IDAF018253
GenAtlas IDTNFRSF11A
HGNC IDHGNC:11908
General References
  1. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9. [Article]
  2. Sirinian C, Papanastasiou AD, Zarkadis IK, Kalofonos HP: Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB. Gene. 2013 Aug 1;525(1):124-9. doi: 10.1016/j.gene.2013.04.075. Epub 2013 May 7. [Article]
  3. Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K: RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 1998 Dec 18;253(2):395-400. [Article]
  4. Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem. 1998 Oct 23;273(43):28355-9. [Article]
  5. Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005 Apr;11(4):394-9. Epub 2005 Mar 6. [Article]
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  7. Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L, Anderson DM: Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet. 2000 Jan;24(1):45-8. [Article]
  8. Guerrini MM, Sobacchi C, Cassani B, Abinun M, Kilic SS, Pangrazio A, Moratto D, Mazzolari E, Clayton-Smith J, Orchard P, Coxon FP, Helfrich MH, Crockett JC, Mellis D, Vellodi A, Tezcan I, Notarangelo LD, Rogers MJ, Vezzoni P, Villa A, Frattini A: Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet. 2008 Jul;83(1):64-76. doi: 10.1016/j.ajhg.2008.06.015. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05959ENMD-1198investigationalunknownDetails