DNA-directed RNA polymerase subunit alpha
Details
- Name
- DNA-directed RNA polymerase subunit alpha
- Synonyms
- 2.7.7.6
- RNA polymerase subunit alpha
- RNAP subunit alpha
- Transcriptase subunit alpha
- Gene Name
- rpoA
- Organism
- Thermus thermophilus
- Amino acid sequence
>lcl|BSEQ0012354|DNA-directed RNA polymerase subunit alpha MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIED VLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQ VEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAK EPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLE EIKEALEKKGFTLKE
- Number of residues
- 315
- Molecular Weight
- 35012.91
- Theoretical pI
- 4.64
- GO Classification
- FunctionsDNA binding / DNA-directed RNA polymerase activityProcessesDNA repair / transcription, DNA-templated
- General Function
- Dna-directed rna polymerase activity
- Specific Function
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Z9H6 UniProtKB Entry Name RPOA_THETH - General References
- Wada T, Yamazaki T, Kyogoku Y: The structure and the characteristic DNA binding property of the C-terminal domain of the RNA polymerase alpha subunit from Thermus thermophilus. J Biol Chem. 2000 May 26;275(21):16057-63. [Article]
- Vassylyev DG, Sekine S, Laptenko O, Lee J, Vassylyeva MN, Borukhov S, Yokoyama S: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature. 2002 Jun 13;417(6890):712-9. Epub 2002 May 8. [Article]