DNA-directed RNA polymerase subunit alpha

Details

Name
DNA-directed RNA polymerase subunit alpha
Synonyms
  • 2.7.7.6
  • RNA polymerase subunit alpha
  • RNAP subunit alpha
  • Transcriptase subunit alpha
Gene Name
rpoA
Organism
Thermus thermophilus
Amino acid sequence
>lcl|BSEQ0012354|DNA-directed RNA polymerase subunit alpha
MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIED
VLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV
EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQ
VEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAK
EPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLE
EIKEALEKKGFTLKE
Number of residues
315
Molecular Weight
35012.91
Theoretical pI
4.64
GO Classification
Functions
DNA binding / DNA-directed RNA polymerase activity
Processes
DNA repair / transcription, DNA-templated
General Function
Dna-directed rna polymerase activity
Specific Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9Z9H6
UniProtKB Entry NameRPOA_THETH
General References
  1. Wada T, Yamazaki T, Kyogoku Y: The structure and the characteristic DNA binding property of the C-terminal domain of the RNA polymerase alpha subunit from Thermus thermophilus. J Biol Chem. 2000 May 26;275(21):16057-63. [Article]
  2. Vassylyev DG, Sekine S, Laptenko O, Lee J, Vassylyeva MN, Borukhov S, Yokoyama S: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature. 2002 Jun 13;417(6890):712-9. Epub 2002 May 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08226Myxopyronin BexperimentalunknownDetails