Glutamate racemase
Details
- Name
- Glutamate racemase
- Synonyms
- 5.1.1.3
- glr
- Gene Name
- murI
- Organism
- Helicobacter pylori (strain J99 / ATCC 700824)
- Amino acid sequence
>lcl|BSEQ0017428|Glutamate racemase MKIGVFDSGVGGFSVLKSLLKARLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKP HEIELLIVACNTASALALEEMQKYSKIPIVGVIEPSILAIKRQVEDKNAPILVLGTKATI QSNAYDNALKQQGYLNISHLATSLFVPLIEESILEGELLETCMHYYFTPLEILPEVIILG CTHFPLIAQKIEGYFMGHFALPTPPLLIHSGDAIVEYLQQKYALKNNACTFPKVEFHASG DVIWLERQAKEWLKL
- Number of residues
- 255
- Molecular Weight
- 28502.97
- Theoretical pI
- 5.6
- GO Classification
- Functionsglutamate racemase activityProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape
- General Function
- Glutamate racemase activity
- Specific Function
- Provides the (R)-glutamate required for cell wall biosynthesis.
- Pfam Domain Function
- Asp_Glu_race (PF01177)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017429|Glutamate racemase (murI) ATGAAAATAGGCGTTTTTGATAGCGGTGTGGGGGGGTTTAGCGTTTTAAAAAGCCTTTTA AAAGCGCGATTGTTTGATGAAATCATCTACTATGGCGATAGCGCTAGAGTGCCTTATGGC ACTAAAGACCCCACCACGATCAAGCAATTTGGCTTAGAGGCTTTGGATTTTTTCAAACCG CATGAGATTGAATTATTGATTGTGGCATGCAACACCGCGAGCGCTCTGGCTTTAGAAGAG ATGCAAAAGTATTCTAAAATCCCTATTGTGGGCGTGATTGAGCCAAGCATTTTAGCGATC AAGCGGCAAGTGGAAGATAAAAACGCCCCTATTTTAGTGCTAGGGACAAAAGCGACGATT CAATCCAACGCCTATGACAACGCCCTGAAACAACAAGGCTATTTGAACATTTCGCATTTA GCTACTTCTCTTTTTGTGCCTTTGATTGAAGAAAGTATTTTAGAGGGCGAATTGTTAGAA ACTTGCATGCATTATTATTTCACTCCCTTAGAGATTTTACCCGAAGTGATCATTTTAGGT TGCACGCATTTTCCCTTAATCGCTCAAAAAATTGAGGGCTATTTCATGGGGCATTTTGCC CTTCCAACGCCCCCCCTACTCATCCATTCGGGCGATGCTATTGTAGAATATTTGCAACAA AAATACGCCCTTAAAAACAATGCATGCACATTCCCTAAAGTGGAATTTCATGCGAGCGGC GATGTGATCTGGCTAGAAAGACAAGCTAAAGAATGGCTCAAATTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9ZLT0 UniProtKB Entry Name MURI_HELPJ GenBank Protein ID 4154504 GenBank Gene ID AE001439 - General References
- Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, Smith DR, Noonan B, Guild BC, deJonge BL, Carmel G, Tummino PJ, Caruso A, Uria-Nickelsen M, Mills DM, Ives C, Gibson R, Merberg D, Mills SD, Jiang Q, Taylor DE, Vovis GF, Trust TJ: Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999 Jan 14;397(6715):176-80. [Article]
- Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL: Exploitation of structural and regulatory diversity in glutamate racemases. Nature. 2007 Jun 14;447(7146):817-22. [Article]
- Geng B, Basarab G, Comita-Prevoir J, Gowravaram M, Hill P, Kiely A, Loch J, MacPherson L, Morningstar M, Mullen G, Osimboni E, Satz A, Eyermann C, Lundqvist T: Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines. Bioorg Med Chem Lett. 2009 Feb 1;19(3):930-6. doi: 10.1016/j.bmcl.2008.11.113. Epub 2008 Dec 6. [Article]
- Basarab GS, Hill P, Eyermann CJ, Gowravaram M, Kack H, Osimoni E: Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5600-7. doi: 10.1016/j.bmcl.2012.07.004. Epub 2012 Jul 20. [Article]