Tetraethylammonium chlorideProduct ingredient for Tetraethylammonium

Name
Tetraethylammonium chloride
Drug Entry
Tetraethylammonium

Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium.

Accession Number
DBSALT000174
Structure
Synonyms
Not Available
UNII
8B82Z83XNN
CAS Number
56-34-8
Weight
Average: 165.704
Monoisotopic: 165.128427352
Chemical Formula
C8H20ClN
InChI Key
YMBCJWGVCUEGHA-UHFFFAOYSA-M
InChI
InChI=1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
IUPAC Name
tetraethylazanium chloride
SMILES
[Cl-].CC[N+](CC)(CC)CC
PubChem Compound
5946
ChemSpider
5733
ChEBI
78161
ChEMBL
CHEMBL434435
Wikipedia
Tetraethylammonium_chloride
Predicted Properties
PropertyValueSource
Water Solubility0.00231 mg/mLALOGPS
logP-0.71ALOGPS
logP-2.5Chemaxon
logS-4.9ALOGPS
Physiological Charge1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity54.9 m3·mol-1Chemaxon
Polarizability17.32 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon