Cerivastatin sodiumProduct ingredient for Cerivastatin
- Name
- Cerivastatin sodium
- Drug Entry
- Cerivastatin
On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.1,2
- Accession Number
- DBSALT000330
- Structure
Structure for Cerivastatin sodium (DBSALT000330)
- Synonyms
- Not Available
- UNII
- 6Q18G1060S
- CAS Number
- 143201-11-0
- Weight
- Average: 481.5321
Monoisotopic: 481.224046051 - Chemical Formula
- C26H33FNNaO5
- InChI Key
- GPUADMRJQVPIAS-ASTDGNLGSA-M
- InChI
- InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;
- IUPAC Name
- sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
- SMILES
- [Na+].[H]\C(=C(\[H])[C@@]([H])(O)C[C@@]([H])(O)CC([O-])=O)C1=C(C2=CC=C(F)C=C2)C(COC)=C(N=C1C(C)C)C(C)C
- External Links
- PubChem Compound
- 23663992
- ChemSpider
- 10632269
- ChEBI
- 3559
- Wikipedia
- Cerivastatin
- Predicted Properties
Property Value Source Water Solubility 0.00663 mg/mL ALOGPS logP 4.22 ALOGPS logP 2.67 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 4.05 Chemaxon pKa (Strongest Basic) 5.58 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 102.71 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 137.66 m3·mol-1 Chemaxon Polarizability 49.26 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon