Pipotiazine palmitateProduct ingredient for Pipotiazine

Name
Pipotiazine palmitate
Drug Entry
Pipotiazine

Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Accession Number
DBSALT001196
Structure
Synonyms
Not Available
UNII
4Q3H01QRMI
CAS Number
37517-26-3
Weight
Average: 714.08
Monoisotopic: 713.425999869
Chemical Formula
C40H63N3O4S2
InChI Key
KTOYYUONFQWSMW-UHFFFAOYSA-N
InChI
InChI=1S/C40H63N3O4S2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-22-40(44)47-32-27-34-25-30-42(31-26-34)28-19-29-43-36-20-17-18-21-38(36)48-39-24-23-35(33-37(39)43)49(45,46)41(2)3/h17-18,20-21,23-24,33-34H,4-16,19,22,25-32H2,1-3H3
IUPAC Name
2-(1-{3-[2-(dimethylsulfamoyl)-10H-phenothiazin-10-yl]propyl}piperidin-4-yl)ethyl hexadecanoate
SMILES
CCCCCCCCCCCCCCCC(=O)OCCC1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)S(=O)(=O)N(C)C)CC1
Human Metabolome Database
HMDB0256583
ChemSpider
34634
ChEBI
135769
ChEMBL
CHEMBL2106439
ZINC
ZINC000008214658
Wikipedia
Pipotiazine
Predicted Properties
PropertyValueSource
Water Solubility2.66e-05 mg/mLALOGPS
logP8.46ALOGPS
logP10.05Chemaxon
logS-7.4ALOGPS
pKa (Strongest Basic)8.86Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area70.16 Å2Chemaxon
Rotatable Bond Count23Chemaxon
Refractivity207.71 m3·mol-1Chemaxon
Polarizability86.8 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon