Pipotiazine palmitateProduct ingredient for Pipotiazine
- Name
- Pipotiazine palmitate
- Drug Entry
- Pipotiazine
Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
- Accession Number
- DBSALT001196
- Structure
- Synonyms
- Not Available
- UNII
- 4Q3H01QRMI
- CAS Number
- 37517-26-3
- Weight
- Average: 714.08
Monoisotopic: 713.425999869 - Chemical Formula
- C40H63N3O4S2
- InChI Key
- KTOYYUONFQWSMW-UHFFFAOYSA-N
- InChI
- InChI=1S/C40H63N3O4S2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-22-40(44)47-32-27-34-25-30-42(31-26-34)28-19-29-43-36-20-17-18-21-38(36)48-39-24-23-35(33-37(39)43)49(45,46)41(2)3/h17-18,20-21,23-24,33-34H,4-16,19,22,25-32H2,1-3H3
- IUPAC Name
- 2-(1-{3-[2-(dimethylsulfamoyl)-10H-phenothiazin-10-yl]propyl}piperidin-4-yl)ethyl hexadecanoate
- SMILES
- CCCCCCCCCCCCCCCC(=O)OCCC1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)S(=O)(=O)N(C)C)CC1
- External Links
- Human Metabolome Database
- HMDB0256583
- ChemSpider
- 34634
- ChEBI
- 135769
- ChEMBL
- CHEMBL2106439
- ZINC
- ZINC000008214658
- Wikipedia
- Pipotiazine
- Predicted Properties
Property Value Source Water Solubility 2.66e-05 mg/mL ALOGPS logP 8.46 ALOGPS logP 10.05 Chemaxon logS -7.4 ALOGPS pKa (Strongest Basic) 8.86 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 70.16 Å2 Chemaxon Rotatable Bond Count 23 Chemaxon Refractivity 207.71 m3·mol-1 Chemaxon Polarizability 86.8 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon