Propiomazine hydrochlorideProduct ingredient for Propiomazine
- Name
- Propiomazine hydrochloride
- Drug Entry
- Propiomazine
Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
- Accession Number
- DBSALT001417
- Structure
Structure for Propiomazine hydrochloride (DBSALT001417)
- Synonyms
- Propiomazine HCl
- UNII
- 70BO17YR03
- CAS Number
- 1240-15-9
- Weight
- Average: 376.94
Monoisotopic: 376.1376123 - Chemical Formula
- C20H25ClN2OS
- InChI Key
- UGVNGSMLNPWNNA-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H24N2OS.ClH/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;/h6-12,14H,5,13H2,1-4H3;1H
- IUPAC Name
- 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one hydrochloride
- SMILES
- Cl.CCC(=O)C1=CC=C2SC3=CC=CC=C3N(CC(C)N(C)C)C2=C1
- External Links
- KEGG Compound
- C07384
- ChemSpider
- 64827
- ChEBI
- 8492
- ChEMBL
- CHEMBL1201068
- Wikipedia
- Propiomazine
- Predicted Properties
Property Value Source Water Solubility 0.00703 mg/mL ALOGPS logP 4.53 ALOGPS logP 4.55 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 16.64 Chemaxon pKa (Strongest Basic) 8.32 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 23.55 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 103.53 m3·mol-1 Chemaxon Polarizability 39.15 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon