Dihydrostreptomycin sulfateProduct ingredient for Dihydrostreptomycin
- Name
- Dihydrostreptomycin sulfate
- Drug Entry
- Dihydrostreptomycin
Dihydrostreptomycin is an aminoglycoside antibiotic. In humans, the use of dihydrostreptomycin has been associated with ototoxicity. The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate.11
- Accession Number
- DBSALT001676
- Structure
Structure for Dihydrostreptomycin sulfate (DBSALT001676)
- Synonyms
- Dihydrostreptomycin sulfate / Dihydrostreptomycin sulphate
- UNII
- T7D4876IUE
- CAS Number
- 5490-27-7
- Weight
- Average: 1461.41
Monoisotopic: 1460.464778732 - Chemical Formula
- C42H88N14O36S3
- InChI Key
- CZWJCQXZZJHHRH-YCRXJPFRSA-N
- InChI
- InChI=1S/2C21H41N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;;;/m00.../s1
- IUPAC Name
- bis(N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
- SMILES
- OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)CO.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)CO
- External Links
- ChemSpider
- 20352
- ChEMBL
- CHEMBL3188576
- Wikipedia
- Dihydrostreptomycin_sulfate
- Predicted Properties
Property Value Source Water Solubility 16.0 mg/mL ALOGPS logP -3 ALOGPS logP -7.3 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 12.11 Chemaxon pKa (Strongest Basic) 11.31 Chemaxon Physiological Charge 3 Chemaxon Hydrogen Acceptor Count 19 Chemaxon Hydrogen Donor Count 15 Chemaxon Polar Surface Area 334.59 Å2 Chemaxon Rotatable Bond Count 18 Chemaxon Refractivity 150.45 m3·mol-1 Chemaxon Polarizability 56.69 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon