Normethadone hydrochlorideProduct ingredient for Normethadone
- Name
- Normethadone hydrochloride
- Drug Entry
- Normethadone
Normethadone is used as an opioid antitussive in combination with Oxilofrine. It is marketed in Canada by Valeant under the tradename Cophylac.
- Accession Number
- DBSALT001919
- Structure
Structure for Normethadone hydrochloride (DBSALT001919)
- Synonyms
- 6-dimethylamino-4,4-diphenylhexan-3-one hydrochloride / Dacartil hydrochloride / Desmethylmethadone hydrochloride / Isoamidone I hydrochloride
- External IDs
- MCV-4457 / NIH-10385 / UM 118
- UNII
- OIV53II16G
- CAS Number
- 847-84-7
- Weight
- Average: 331.88
Monoisotopic: 331.1702922 - Chemical Formula
- C20H26ClNO
- InChI Key
- GYWUCVKLUKFJLC-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H25NO.ClH/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14H,4,15-16H2,1-3H3;1H
- IUPAC Name
- 6-(dimethylamino)-4,4-diphenylhexan-3-one hydrochloride
- SMILES
- Cl.CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 12748
- Predicted Properties
Property Value Source Water Solubility 0.00737 mg/mL ALOGPS logP 3.84 ALOGPS logP 4.59 Chemaxon logS -4.6 ALOGPS pKa (Strongest Acidic) 18.8 Chemaxon pKa (Strongest Basic) 8.83 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 20.31 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 92.85 m3·mol-1 Chemaxon Polarizability 34.67 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon