Golvatinib TartrateProduct ingredient for Golvatinib
- Name
- Golvatinib Tartrate
- Drug Entry
- Golvatinib
Golvatinib has been investigated for the treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck.
- Accession Number
- DBSALT002115
- Structure
Structure for Golvatinib Tartrate (DBSALT002115)
- Synonyms
- Not Available
- UNII
- 47S9L68C0N
- CAS Number
- 1007601-96-8
- Weight
- Average: 783.787
Monoisotopic: 783.303946939 - Chemical Formula
- C37H43F2N7O10
- InChI Key
- JYFKDBFPRXMUAM-LREBCSMRSA-N
- InChI
- InChI=1S/C33H37F2N7O4.C4H6O6/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23;5-1(3(7)8)2(6)4(9)10/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; N'1-{2-fluoro-4-[(2-{[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CCN(CC1)C1CCN(CC1)C(=O)NC1=CC(OC2=CC=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C(F)=C2)=CC=N1
- External Links
- ChemSpider
- 30790729
- Predicted Properties
Property Value Source Water Solubility 0.0403 mg/mL ALOGPS logP 3.19 ALOGPS logP 3.56 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 11.38 Chemaxon pKa (Strongest Basic) 8.26 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 119.14 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 172.48 m3·mol-1 Chemaxon Polarizability 64.23 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon