Dalfopristin mesylateProduct ingredient for Dalfopristin
- Name
- Dalfopristin mesylate
- Drug Entry
- Dalfopristin
Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
- Accession Number
- DBSALT002330
- Structure
- Synonyms
- Not Available
- UNII
- R5U9EZY06G
- CAS Number
- Not Available
- Weight
- Average: 786.95
Monoisotopic: 786.317965543 - Chemical Formula
- C35H54N4O12S2
- InChI Key
- ZUBXFMSQBHKVNC-ODOOVVHSSA-N
- InChI
- InChI=1S/C34H50N4O9S.CH4O3S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42;1-5(2,3)4/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41);1H3,(H,2,3,4)/b10-9+,12-11+,23-18+;/t24-,25-,28-,31-,32-;/m1./s1
- IUPAC Name
- (6R,7S,10R,11R,12E,17E,19E,21S)-6-[2-(diethylamino)ethanesulfonyl]-21-hydroxy-11,19-dimethyl-10-(propan-2-yl)-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone; methanesulfonic acid
- SMILES
- CS(O)(=O)=O.[H]N1C\C=C\C(\C)=C\[C@@H](O)CC(=O)CC2=NC(=CO2)C(=O)N2CC[C@H]([C@@H]2C(=O)O[C@H](C(C)C)[C@H](C)\C=C\C1=O)S(=O)(=O)CCN(CC)CC
- External Links
- ChemSpider
- 34993593
- Predicted Properties
Property Value Source Water Solubility 0.0716 mg/mL ALOGPS logP 2.57 ALOGPS logP 1.58 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 13.17 Chemaxon pKa (Strongest Basic) 7.09 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 176.42 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 182.84 m3·mol-1 Chemaxon Polarizability 73.43 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon