Amuvatinib hydrochlorideProduct ingredient for Amuvatinib
- Name
- Amuvatinib hydrochloride
- Drug Entry
- Amuvatinib
Amuvatinib has been used in trials studying the treatment of Solid Tumors and Small Cell Lung Carcinoma. Amuvatinib is an oral, selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer cells.
- Accession Number
- DBSALT002365
- Structure
- Synonyms
- Not Available
- UNII
- 14L8O2K12B
- CAS Number
- 1055986-67-8
- Weight
- Average: 483.97
Monoisotopic: 483.1131885 - Chemical Formula
- C23H22ClN5O3S
- InChI Key
- IKQFRXPMBGQJGE-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H21N5O3S.ClH/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21;/h1-6,11,13H,7-10,12,14H2,(H,24,32);1H
- IUPAC Name
- N-[(2H-1,3-benzodioxol-5-yl)methyl]-4-{8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl}piperazine-1-carbothioamide hydrochloride
- SMILES
- Cl.S=C(NCC1=CC=C2OCOC2=C1)N1CCN(CC1)C1=NC=NC2=C1OC1=C2C=CC=C1
- External Links
- ChemSpider
- 17218420
- ChEMBL
- CHEMBL2105685
- Predicted Properties
Property Value Source Water Solubility 0.0741 mg/mL ALOGPS logP 2.79 ALOGPS logP 3.52 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 14.11 Chemaxon pKa (Strongest Basic) 1.37 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 75.89 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 124.53 m3·mol-1 Chemaxon Polarizability 47.82 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon