Terazosin hydrochloride hydrateProduct ingredient for Terazosin

Name
Terazosin hydrochloride hydrate
Drug Entry
Terazosin

Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertensionLabel1. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate2.

Accession Number
DBSALT002382
Structure
Synonyms
Terazosin hydrochloride / Terazosin hydrochloride dihydrate / Terazosin monohydrochloride dihydrate
External IDs
ABBOTT-45975
UNII
D32S14F082
CAS Number
70024-40-7
Weight
Average: 441.91
Monoisotopic: 441.1778967
Chemical Formula
C19H28ClN5O5
InChI Key
MWYNOTLRCUQCKD-UHFFFAOYSA-N
InChI
InChI=1S/C19H25N5O4.ClH.H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;1H2
IUPAC Name
6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine hydrate hydrochloride
SMILES
O.Cl.COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N1CCN(CC1)C(=O)C1CCCO1
ChemSpider
7979122
ChEMBL
CHEMBL1201091
Predicted Properties
PropertyValueSource
Water Solubility1.5 mg/mLALOGPS
logP1.12ALOGPS
logP1.18Chemaxon
logS-2.4ALOGPS
pKa (Strongest Acidic)19.93Chemaxon
pKa (Strongest Basic)7.24Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area103.04 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity105.18 m3·mol-1Chemaxon
Polarizability41.67 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon