Moxonidine hydrochlorideProduct ingredient for Moxonidine

Name
Moxonidine hydrochloride
Drug Entry
Moxonidine

Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.

Accession Number
DBSALT002876
Structure
Synonyms
Moxonidine HCl
UNII
5RYW07SK5E
CAS Number
75438-58-3
Weight
Average: 278.14
Monoisotopic: 277.0497155
Chemical Formula
C9H13Cl2N5O
InChI Key
ZZPAWQYZQVUVHX-UHFFFAOYSA-N
InChI
InChI=1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
IUPAC Name
4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrochloride
SMILES
Cl.COC1=NC(C)=NC(Cl)=C1NC1=NCCN1
ChemSpider
9406303
ChEMBL
CHEMBL1256287
Predicted Properties
PropertyValueSource
Water Solubility0.114 mg/mLALOGPS
logP1.01ALOGPS
logP1.54Chemaxon
logS-3.3ALOGPS
pKa (Strongest Basic)7.26Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area71.43 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity63.41 m3·mol-1Chemaxon
Polarizability23.57 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon