Fimasartan potassium anhydrousProduct ingredient for Fimasartan

Name
Fimasartan potassium anhydrous
Drug Entry
Fimasartan

Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.

Accession Number
DBSALT003078
Structure
Synonyms
Not Available
UNII
T2ICP7GBBN
CAS Number
1402813-38-0
Weight
Average: 539.74
Monoisotopic: 539.18696128
Chemical Formula
C27H30KN7OS
InChI Key
OCKQGXSJNJCCDO-UHFFFAOYSA-N
InChI
InChI=1S/C27H30N7OS.K/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26;/h7-10,12-15H,5-6,11,16-17H2,1-4H3;/q-1;+1
IUPAC Name
potassium 5-[4'-({2-butyl-5-[(dimethylcarbamothioyl)methyl]-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl}methyl)-[1,1'-biphenyl]-2-yl]-1H-1,2,3,4-tetrazol-1-ide
SMILES
[K+].CCCCC1=NC(C)=C(CC(=S)N(C)C)C(=O)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=N[N-]1
ChemSpider
52084781
Predicted Properties
PropertyValueSource
Water Solubility0.00542 mg/mLALOGPS
logP4.03ALOGPS
logP3.38Chemaxon
logS-5ALOGPS
pKa (Strongest Acidic)4.6Chemaxon
pKa (Strongest Basic)4.47Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area87.47 Å2Chemaxon
Rotatable Bond Count9Chemaxon
Refractivity161.85 m3·mol-1Chemaxon
Polarizability54.12 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon