Sodium pidolateProduct ingredient for Pidolic acid

Name
Sodium pidolate
Drug Entry
Pidolic acid

Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways 4,7. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism 7. Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin 7.

There are currently little to no medicines available that are clinically approved or marketed for employing pidolic acid as an active ingredient for any particular formal indication. Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for the proposed purpose of facilitating cognitive or memory enhancement, most available research suggest exercising caution in their recommendation as much more research is necessary 1,2.

Accession Number
DBSALT003084
Structure
Synonyms
PCA soda / Sodium DL-pyroglutamate / Sodium PCA / Sodium pyrrolidone carboxylate
External IDs
259-234-9 / AJIDEW N-50
UNII
469OTG57A2
CAS Number
54571-67-4
Weight
Average: 151.097
Monoisotopic: 151.02453734
Chemical Formula
C5H6NNaO3
InChI Key
CRPCXAMJWCDHFM-UHFFFAOYSA-M
InChI
InChI=1S/C5H7NO3.Na/c7-4-2-1-3(6-4)5(8)9;/h3H,1-2H2,(H,6,7)(H,8,9);/q;+1/p-1
IUPAC Name
sodium 5-oxopyrrolidine-2-carboxylate
SMILES
[Na+].[O-]C(=O)C1CCC(=O)N1
ChemSpider
2006579
Predicted Properties
PropertyValueSource
Water Solubility424.0 mg/mLALOGPS
logP-0.97ALOGPS
logP-0.89Chemaxon
logS0.45ALOGPS
pKa (Strongest Acidic)3.61Chemaxon
pKa (Strongest Basic)-2.2Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area69.23 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity38.92 m3·mol-1Chemaxon
Polarizability11.17 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon