Bendazac lysineProduct ingredient for Bendazac
- Name
- Bendazac lysine
- Drug Entry
- Bendazac
Bendazac is an oxyacetic acid 1,2. Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, most research has revolved around studying and demonstrating the agent's principal action in inhibiting the denaturation of proteins - an effect that has primarily proven useful in managing and delaying the progression of ocular cataracts 1,1. Bendazac, however, has since been withdrawn or discontinued in various international regions due to its capability or risk for eliciting hepatotoxicity 4,5,6,10 in patients although a small handful of regions may continue to have the medication available for purchase and use either as a topical anti-inflammatory/analgesic cream or eye drop formulation.
- Accession Number
- DBSALT003088
- Structure
- Synonyms
- Bendazac lysinate / Bendazac lysine salt
- External IDs
- AF 1934 / AF-1934
- UNII
- CL7T957EGC
- CAS Number
- 81919-14-4
- Weight
- Average: 428.489
Monoisotopic: 428.205970018 - Chemical Formula
- C22H28N4O5
- InChI Key
- OCOCFNMFLNFNIA-ZSCHJXSPSA-N
- InChI
- InChI=1S/C16H14N2O3.C6H14N2O2/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12;7-4-2-1-3-5(8)6(9)10/h1-9H,10-11H2,(H,19,20);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
- IUPAC Name
- (2S)-2,6-diaminohexanoic acid; 2-[(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
- SMILES
- NCCCC[C@H](N)C(O)=O.OC(=O)COC1=NN(CC2=CC=CC=C2)C2=C1C=CC=C2
- External Links
- ChemSpider
- 19966376
- ChEMBL
- CHEMBL1089222
- Predicted Properties
Property Value Source Water Solubility 0.103 mg/mL ALOGPS logP 2.89 ALOGPS logP 3.06 Chemaxon logS -3.4 ALOGPS pKa (Strongest Acidic) 3.66 Chemaxon pKa (Strongest Basic) -0.055 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 64.35 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 88.76 m3·mol-1 Chemaxon Polarizability 29.09 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon