Mitoquinone mesylateProduct ingredient for Mitoquinone
- Name
- Mitoquinone mesylate
- Drug Entry
- Mitoquinone
Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct molecular link between mitochondrial dysfunction and the pathogenesis of Parkinson's disease. Mitochondrial dysfunction also has been shown to represent an early critical event in the pathogenesis of the sporadic form of Parkinson's disease. Clinical studies by the Parkinson's Study Group show that very high doses of an antioxidant called Coenzyme Q (which Mitoquinone effectively targets into mitochondria) appear to slow the progression of Parkinson's disease symptoms.
- Accession Number
- DBSALT003175
- Structure
Structure for Mitoquinone mesylate (DBSALT003175)
- Synonyms
- Mitoquinone methanesulfonate
- UNII
- 6E01CG547T
- CAS Number
- 845959-50-4
- Weight
- Average: 678.82
Monoisotopic: 678.278012025 - Chemical Formula
- C38H47O7PS
- InChI Key
- GVZFUVXPTPGOQT-UHFFFAOYSA-M
- InChI
- InChI=1S/C37H44O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32;1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1
- IUPAC Name
- [10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl]triphenylphosphanium methanesulfonate
- SMILES
- CS([O-])(=O)=O.COC1=C(OC)C(=O)C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)=C(C)C1=O
- External Links
- ChemSpider
- 9563239
- ChEMBL
- CHEMBL4074884
- Predicted Properties
Property Value Source Water Solubility 3.98e-06 mg/mL ALOGPS logP 6.01 ALOGPS logP 8.71 Chemaxon logS -8.2 ALOGPS pKa (Strongest Basic) -4.7 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 52.6 Å2 Chemaxon Rotatable Bond Count 16 Chemaxon Refractivity 175.48 m3·mol-1 Chemaxon Polarizability 67.54 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon