Fluorouracil sodiumProduct ingredient for Fluorouracil

Show full entry for Fluorouracil
Name
Fluorouracil sodium
Drug Entry
Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

See full entry for Fluorouracil
Accession Number
DBSALT003208
Structure
Similar Structures
Synonyms
5-Fluorouracil sodium salt / Sodium fluorouracil
UNII
PM476L7O8G
CAS Number
14787-18-9
Weight
Average: 152.06
Monoisotopic: 151.99979976
Chemical Formula
C4H2FN2NaO2
InChI Key
XLBUSGPKSVRQSF-UHFFFAOYSA-M
InChI
InChI=1S/C4H3FN2O2.Na/c5-2-1-6-4(9)7-3(2)8;/h1H,(H2,6,7,8,9);/q;+1/p-1
IUPAC Name
sodium 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-ide
SMILES
[Na+].FC1=CNC(=O)[N-]C1=O
ChemSpider
8305571
Predicted Properties
PropertyValueSource
Water Solubility41.5 mg/mLALOGPS
logP-0.79ALOGPS
logP-0.66Chemaxon
logS-0.56ALOGPS
pKa (Strongest Acidic)7.18Chemaxon
pKa (Strongest Basic)-8Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area55.4 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity25.37 m3·mol-1Chemaxon
Polarizability9.09 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon