Mrv0541 04191212112D          

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M  END
> <DATABASE_ID>
DB00275

> <DATABASE_NAME>
drugbank

> <SMILES>
CCCC1=NC(=C(N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1)C(O)=O)C(C)(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

> <INCHI_KEY>
VTRAEEWXHOVJFV-UHFFFAOYSA-N

> <FORMULA>
C24H26N6O3

> <MOLECULAR_WEIGHT>
446.5016

> <EXACT_MASS>
446.206638728

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
59

> <JCHEM_AVERAGE_NEUTRAL_MICROSPECIES_CHARGE>
-1.9006130940999542

> <JCHEM_AVERAGE_POLARIZABILITY>
47.52384277662581

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid

> <ALOGPS_LOGP>
2.98

> <JCHEM_LOGP>
2.1579002673482983

> <ALOGPS_LOGS>
-4.63

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NEUTRAL_CHARGE>
-2

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
4.943020612909525

> <JCHEM_PKA_STRONGEST_ACIDIC>
0.8851026710720384

> <JCHEM_PKA_STRONGEST_BASIC>
5.325080924969429

> <JCHEM_POLAR_SURFACE_AREA>
129.81

> <JCHEM_REFRACTIVITY>
137.3237

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.05e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
biotin

> <JCHEM_VEBER_RULE>
0

> <DRUGBANK_ID>
DB00275

> <SECONDARY_ACCESSION_NUMBERS>
APRD00223

> <DRUG_GROUPS>
approved; investigational

> <GENERIC_NAME>
Olmesartan

> <SYNONYMS>
4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid; 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid; Olmesartan

> <PRODUCTS>
AMLODIPINE and OLMESARTAN medoxomil; Ach-olmesartan; Ach-olmesartan Hctz; Ag-olmesartan; Ag-olmesartan Hctz; Amlodipine Besylate and Olmesartan Medoxomil; Amlodipine and Olmesartan Medoxomil; Amlodipine and olmesartan Medoxomil; Amlodipine and olmesartan medoxomil; Amlodipine besylate and Olmesartan medoxomil; Amlodipine besylate and Olmesartran medoxomil; Apo-olmesartan; Apo-olmesartan/hctz; Auro-olmesartan; Auro-olmesartan Hctz; Azor; Benicar; Benicar HCT; Benicar Hct; Gln-olmesartan; Gln-olmesartan Hctz; Jamp Olmesartan; Jamp-olmesartan Hctz; M-olmesartan; Med-olmesartan; Nra-olmesartan; Nra-olmesartan Hctz; OLMESARTAN MEDOXOMIL and HYDROCHLOROTHIAZIDE; Olmesartan; Olmesartan Medoxmil and Hydrochlorothiazide; Olmesartan Medoxomil; Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide; Olmesartan Medoxomil / Hydrochlorothiazide; Olmesartan Medoxomil and Hydrochlorothiazide; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg; Olmesartan Medoxomil-hydrochlorothiazide; Olmesartan Medoxomil/hctz; Olmesartan medoxomil; Olmesartan/hctz; Olmetec; Olmetec Plus; PMS-olmesartan; PMS-olmesartan-hctz; Prz-olmesartan; Prz-olmesartan/hctz; Riva-olmesartan; Sandoz Olmesartan; Sandoz Olmesartan Hctz; Teva-olmesartan; Teva-olmesartan / HCT; Teva-olmesartan/hctz; Tribenzor

> <INTERNATIONAL_BRANDS>
Erastapex; Golme; Olmy; Olsar; Olvance; WinBP

> <SALTS>
Olmesartan medoxomil

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