Displaying drugs 101 - 125 of 677 in total
Sodium aurothiomalate
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Synonyms: … Aurotiomalato sodico ... Gold sodium thiomalate ... Sodium aurothiomalate …
Matched Name: … Sodium aurothiomalate …
Matched Description: … It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence ... Sodium Thiomalate per mL. ... Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... sodium aurothiomalate …
Matched Products: … Sodium Aurothiomalate Injection BP …
Matched Name: … Sodium aurothiomalate …
Matched Description: … It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence ... Sodium Thiomalate per mL. ... Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... sodium aurothiomalate …
Matched Products: … Sodium Aurothiomalate Injection BP …
Tolnaftate
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Approved
Investigational
Vet approved
Matched Description: … and ringworm. ... It is sold under several brand names, most notably Tinactin and Odor Eaters. ... It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot …
Matched Mixtures name: … Terbinafine HCl Chlortimazole and Tolnaftate …
Matched Products: … Defense Antifungal Medicated Bar ... Up and Up Antifungal ... Fungi Nail Toe and Foot …
Matched Mixtures name: … Terbinafine HCl Chlortimazole and Tolnaftate …
Matched Products: … Defense Antifungal Medicated Bar ... Up and Up Antifungal ... Fungi Nail Toe and Foot …
Quercus alba pollen
Quercus alba pollen, or oak white pollen, is a non-standardized allergen extract used for the diagnosis and treatment of allergic disease to grass pollen. It can be subcutaneously administered to initiate an immune response in case of an allergic reaction. Diagnostic allergenic extracts are primarily indicated for establishing clinical relevance...
Approved
Matched Name: … Quercus alba pollen …
Matched Description: … and treatment of allergic disease to grass pollen. ... indicated for establishing clinical relevance of specific allergens to which the patient has been exposed and ... Quercus alba pollen, or oak white pollen, is a non-standardized allergen extract used for the diagnosis …
Matched Products: … Quercus Alba Pollen ... Center-AL - Quercus Alba Pollen …
Matched Description: … and treatment of allergic disease to grass pollen. ... indicated for establishing clinical relevance of specific allergens to which the patient has been exposed and ... Quercus alba pollen, or oak white pollen, is a non-standardized allergen extract used for the diagnosis …
Matched Products: … Quercus Alba Pollen ... Center-AL - Quercus Alba Pollen …
Zanthoxylum clava-herculis bark
Zanthoxylum clava-herculis bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Pepperwood Bark ... Southern Pricky Ask Bark ... Hercules-club Pricklyash Bark …
Matched Name: … Zanthoxylum clava-herculis bark …
Matched Description: … Zanthoxylum clava-herculis bark is a plant/plant extract used in some OTC (over-the-counter) products …
Matched Name: … Zanthoxylum clava-herculis bark …
Matched Description: … Zanthoxylum clava-herculis bark is a plant/plant extract used in some OTC (over-the-counter) products …
Thyme
Thyme allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Garden thyme …
Phenytoin
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Salts name: … Phenytoin sodium …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …
Matched Products: … Phenytoin Sodium ... PHENYTOIN SODIUM ... FENITOINA SODICA …
Matched Salts name: … Phenytoin sodium …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …
Matched Products: … Phenytoin Sodium ... PHENYTOIN SODIUM ... FENITOINA SODICA …
Valerian
Valerian is extracted from a herb that is a perennial flowering plant. Valerian root is reported to have sedative and anxiolytic effects however its mechanism of action is not completely understood. Valerian has been used in the treatment of conditions including sleep disorders, anxiety, attention deficit-hyperactivity disorder (ADHD) and joint...
Approved
Experimental
Investigational
Matched Description: … Valerian root is reported to have sedative and anxiolytic effects however its mechanism of action is ... treatment of conditions including sleep disorders, anxiety, attention deficit-hyperactivity disorder (ADHD) and ... [DB00313] is a derivative of valeric acid, which is obtained from the plant root. …
Matched Mixtures name: … Valerian and Hops Tablets ... Sanhelios Valerian Pearls and Hops …
Matched Categories: … Hypnotics and Sedatives ... Herbs and Natural Products ... Miscellaneous Anxiolytics Sedatives and Hypnotics …
Matched Products: … Valerian Root Cap 470mg ... Valerian Root Capsule 500mg ... Valerian Root 400mg Capsules …
Matched Mixtures name: … Valerian and Hops Tablets ... Sanhelios Valerian Pearls and Hops …
Matched Categories: … Hypnotics and Sedatives ... Herbs and Natural Products ... Miscellaneous Anxiolytics Sedatives and Hypnotics …
Matched Products: … Valerian Root Cap 470mg ... Valerian Root Capsule 500mg ... Valerian Root 400mg Capsules …
Eucommia ulmoides bark
Eucommia ulmoides bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Du Zhong Bark ... Eucommia Bark ... Chinese Rubber Tree Bark …
Matched Name: … Eucommia ulmoides bark …
Matched Description: … Eucommia ulmoides bark is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Eucommia ulmoides bark …
Matched Description: … Eucommia ulmoides bark is a plant/plant extract used in some OTC (over-the-counter) products. …
Antihemophilic factor (recombinant), PEGylated
Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product Adynovate [FDA label].
Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one molecule of...
Approved
Investigational
Matched Description: … PEGylation decreases factor VIII clearance and allowing for an increased duration of drug circulation ... It has been created to increase the half-life of factor VIII, which decreases dose frequency and decreases …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 3000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 250 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 3000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 250 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Hydroquinone
Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids,...
Approved
Investigational
Matched Description: … It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy ... As a result of these concerns, hydroquinone has been banned in the EU and UK. ... Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% ... Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% ... OLIVIA QUIDO FIRM and FADE I …
Matched Products: … ALBUS ... CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector ... CONDITION AND ENHANCE BLENDER Skin Lightener and Blending …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% ... Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% ... OLIVIA QUIDO FIRM and FADE I …
Matched Products: … ALBUS ... CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector ... CONDITION AND ENHANCE BLENDER Skin Lightener and Blending …
Populus alba pollen
Populus alba pollen is the pollen of the Populus alba plant. Populus alba pollen is mainly used in allergenic testing.
Approved
Matched Name: … Populus alba pollen …
Matched Description: … Populus alba pollen is the pollen of the Populus alba plant. ... Populus alba pollen is mainly used in allergenic testing. …
Matched Products: … Populus Alba Pollen ... Center-AL - Populus Alba Pollen …
Matched Description: … Populus alba pollen is the pollen of the Populus alba plant. ... Populus alba pollen is mainly used in allergenic testing. …
Matched Products: … Populus Alba Pollen ... Center-AL - Populus Alba Pollen …
Octinoxate
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often combined with nanoparticles or other water-resistant liposomes in formulations to increase...
Approved
Investigational
Matched Description: … Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize ... Its use in pharmaceutical and cosmetic formulations is approved by FDA. ... nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and …
Matched Mixtures name: … Sodium Sulfacetamide and Sulfur ... ESIKA HYDRACOLOR 2 IN 1 Highly Moisturizing and coloring SPF 25 (MORA GLAM) - BROWN ... ESIKA HYDRACOLOR 2 IN 1 HIGHLY MOISTURIZING AND Coloring SPF 25 (MORA GLAM) - BROWN …
Matched Categories: … Emollients and Protectives …
Matched Products: … Rouge Dior 660 Garnet Serum ... Flawless Finish Bare Perfection Makeup SPF 8 Fawn ... Firming and Moisturizing Body …
Matched Mixtures name: … Sodium Sulfacetamide and Sulfur ... ESIKA HYDRACOLOR 2 IN 1 Highly Moisturizing and coloring SPF 25 (MORA GLAM) - BROWN ... ESIKA HYDRACOLOR 2 IN 1 HIGHLY MOISTURIZING AND Coloring SPF 25 (MORA GLAM) - BROWN …
Matched Categories: … Emollients and Protectives …
Matched Products: … Rouge Dior 660 Garnet Serum ... Flawless Finish Bare Perfection Makeup SPF 8 Fawn ... Firming and Moisturizing Body …
Moroctocog alfa
Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Description: … Bleeding can range in severity from minor concerns, such as nosebleeds, to more serious events such as ... purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which ... Moroctocog alfa is approved by Health Canada and by the European Medicines Agency for the control and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Givastomig
Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody.
Investigational
Matched Synonyms: … an anti-Claudin 18.2 and 4.1BB Bispecific Antibody …
Matched Description: … Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody. …
Matched Description: … Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody. …
Benzoyl peroxide
Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with erythromycin, clindamycin, or adapalene. After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.[A18903,A233859] This treatment decreases keratin and...
Approved
Matched Description: … [A18903,A233859] This treatment decreases keratin and sebum around follicles, as well as increasing turnover …
Matched Mixtures name: … Clease and Treat ... Clean and Clear Advantage 2-in-1 Acne and Mark Eraser Kit ... Erythromycin and Benzoyl Peroxide …
Matched Products: … Panoxyl 5 Bar ... Acne Cleansing Bar ... Panoxyl 10 Bar 10% …
Matched Mixtures name: … Clease and Treat ... Clean and Clear Advantage 2-in-1 Acne and Mark Eraser Kit ... Erythromycin and Benzoyl Peroxide …
Matched Products: … Panoxyl 5 Bar ... Acne Cleansing Bar ... Panoxyl 10 Bar 10% …
Lonoctocog alfa
Approved
Investigational
Matched Products: … AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250IU/VIAL ... AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500IU/VIAL ... AFSTYLA 250IU powder and solvent for solution for injection …
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched International brands: … Bitol Sodium ... Pental Sodyum ... Intraval Sodium …
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Salts name: … Thiopental sodium …
Matched Categories: … Hypnotics and Sedatives …
Matched Products: … Thiopental Sodium ... PENTOTHAL SODIUM ... Pentothal Sodium Pws 5gm …
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Salts name: … Thiopental sodium …
Matched Categories: … Hypnotics and Sedatives …
Matched Products: … Thiopental Sodium ... PENTOTHAL SODIUM ... Pentothal Sodium Pws 5gm …
Tribulus terrestris root
Tribulus terrestris root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Bindii Root ... Goathead Root ... Gokshura Root …
Matched Name: … Tribulus terrestris root …
Matched Description: … Tribulus terrestris root is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Tribulus terrestris root …
Matched Description: … Tribulus terrestris root is a plant/plant extract used in some OTC (over-the-counter) products. …
Rurioctocog alfa pegol
Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous or secondary events like trauma...
Approved
Experimental
Matched Description: … Bleeding in joints is a common manifestation of hemophilia A, and bleeding episodes can be severe and ... alfa pegol aims to restore functional levels of factor VIII in patients with hemophilia A to manage and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 1500IU Powder and Solvent for Solution for Injection ... ADYNOVATE 2000IU Powder and Solvent for Solution for Injection ... ADYNOVATE 1000IU Powder and Solvent for Solution for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 1500IU Powder and Solvent for Solution for Injection ... ADYNOVATE 2000IU Powder and Solvent for Solution for Injection ... ADYNOVATE 1000IU Powder and Solvent for Solution for Injection …
RP-72
Investigational
Matched Synonyms: … CXC chemokine receptor types 1 and 2 inhibitor RP72 ... 72 amino acid proprietary recombinant protein antagonist for the CXCR1 and CXCR2 receptors of interleukin …
Albutrepenonacog alfa
Albutrepenonacog alfa (rIX-RFP) is a recombinant fusion protein that links a recombinant coagulation factor IX (rFIX) with a recombinant human albumin (rAlbumin). It was developed by CSL Behring Canada, Inc and approved by Health Canada on April 26, 2017. It was also approved by FDA and EMA in 2016. It...
Approved
Matched Description: … It was also approved by FDA and EMA in 2016. ... It is currently marketed in the forms of 250, 500, 1000 and 2000 IU/vial.[L2305] ... [A32547] It was developed by CSL Behring Canada, Inc and approved by Health Canada on April 26, 2017. …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Products: … IDELVION 250 IU powder and solvent for solution for injection ... IDELVION 500 IU powder and solvent for solution for injection ... IDELVION 1000 IU powder and solvent for solution for injection …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Products: … IDELVION 250 IU powder and solvent for solution for injection ... IDELVION 500 IU powder and solvent for solution for injection ... IDELVION 1000 IU powder and solvent for solution for injection …
Bacitracin
Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A181997,L7748]
Approved
Vet approved
Matched Mixtures name: … Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone Acetate ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Up and Up First Aid Antibiotic ... Up and Up Bacitracin first aid ... Albac Powder 10% …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Up and Up First Aid Antibiotic ... Up and Up Bacitracin first aid ... Albac Powder 10% …
Degarelix
Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression. Reduction in...
Approved
Matched Description: … derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and ... This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Matched Products: … Firmagon 120mg Powder and Solvent for Solution for Injection ... Firmagon 80mg Powder and Solvent for Solution for Injection ... FIRMAGON Powder and Solvent for Solution for Injection 120 mg …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Matched Products: … Firmagon 120mg Powder and Solvent for Solution for Injection ... Firmagon 80mg Powder and Solvent for Solution for Injection ... FIRMAGON Powder and Solvent for Solution for Injection 120 mg …
Valproic acid
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in ... [A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for ... It is currently a compound of interest in the field of oncology for its anti-proliferative effects and …
Matched Salts name: … Divalproex sodium ... Valproate sodium …
Matched Products: … GARKENE ... Divalproex Sodium ... Valproate Sodium …
Matched Salts name: … Divalproex sodium ... Valproate sodium …
Matched Products: … GARKENE ... Divalproex Sodium ... Valproate Sodium …
Black cohosh
Black cohosh (Actaea racemosa or Cimicifuga racemosa), a member of the buttercup family, is a perennial plant which native to North America. Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism weed. Black cohosh has a long history of use. Native Americans used it for its...
Experimental
Matched Synonyms: … Fairy candle root ... Cimicifuga racemosa root ... Cimicifuga racemosa root with rhizome …
Matched Description: … mood disturbance, and hot flushes. ... Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism ... for its purported benefits in treating musculoskeletal pain, fever, cough, pneumonia, sluggish labor, and …
Matched Categories: … Herbs and Natural Products ... Genito Urinary System and Sex Hormones …
Matched Products: … Black Cohosh Root Powder …
Matched Description: … mood disturbance, and hot flushes. ... Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism ... for its purported benefits in treating musculoskeletal pain, fever, cough, pneumonia, sluggish labor, and …
Matched Categories: … Herbs and Natural Products ... Genito Urinary System and Sex Hormones …
Matched Products: … Black Cohosh Root Powder …
Displaying drugs 101 - 125 of 677 in total