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Displaying drugs 351 - 375 of 375 in total
AN-9
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), exhibited low toxicity and significant anticancer activity in vitro and in vivo. It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA...
Investigational
Matched Iupac: … [(2,2-dimethylpropanoyl)oxy]methyl butanoate …
Matched Description: … and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than ... significant anticancer activity in vitro and in vivo. ... It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition …
Matched Description: … and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than ... significant anticancer activity in vitro and in vivo. ... It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition …
Triglu-5-formyl-tetrahydrofolate
Experimental
Matched Iupac: … (2S)-2-[(4S)-4-[(4S)-4-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino …
Matched Categories: … Folic Acid and Derivatives …
Matched Categories: … Folic Acid and Derivatives …
C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide
Experimental
Matched Iupac: … (2S,3R,4S,5S,6R)-2-[amino(hydroxy)methyl]-2-azido-6-(hydroxymethyl)oxane-3,4,5-triol …
Detomidine
Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan. Currently, it is only approved by the FDA for use in horses but has been studied for...
Vet approved
Matched Iupac: … 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole …
Matched Description: … Normally, it is administered in the salt form, detomidine hydrochloride. ... This drug is prescribed by veterinarians and is marketed as _Dormosedan_. …
Matched Categories: … Hypnotics and Sedatives …
Matched Description: … Normally, it is administered in the salt form, detomidine hydrochloride. ... This drug is prescribed by veterinarians and is marketed as _Dormosedan_. …
Matched Categories: … Hypnotics and Sedatives …
Levopropoxyphene
Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s. Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. This drug presented different dosages and it was administered...
Withdrawn
Matched Iupac: … (2R,3S)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate …
Matched Description: … Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. ... [T133] Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. ... This drug presented different dosages and it was administered as a capsule or suspension. …
Matched Description: … Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. ... [T133] Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. ... This drug presented different dosages and it was administered as a capsule or suspension. …
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone
Experimental
Matched Iupac: … 4-{4-[(2-oxo-2,3-dihydro-1H-indol-3-yl)methyl]phenyl}piperazine-1-carbaldehyde …
Faropenem medoxomil
Faropenem medoxomil is an ester prodrug derivative of the beta-lactam antibiotic faropenem. The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic concentrations of the drug. Faropenem medoxomil is a broad-spectrum antibiotic that is highly resistant to beta-lactamase degradation. It is being developed jointly by...
Investigational
Matched Iupac: … (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]- …
Matched Description: … The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic ... It is being developed jointly by Replidyne, Inc. and Forest Laboratories, Inc. …
Matched Description: … The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic ... It is being developed jointly by Replidyne, Inc. and Forest Laboratories, Inc. …
Ripasudil
Ripasudil, as hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and ocular hypertension. It was first approved for treatment in Japan in September 2014. This medication is available in the form of a 0.4% eye drop solution under the...
Experimental
Matched Iupac: … 4-fluoro-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline …
Matched Description: … This medication is available in the form of a 0.4% eye drop solution under the brand name Glanatec. ... Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and …
Matched Categories: … Antiglaucoma Preparations and Miotics …
Matched Description: … This medication is available in the form of a 0.4% eye drop solution under the brand name Glanatec. ... Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and …
Matched Categories: … Antiglaucoma Preparations and Miotics …
Tenofovir
Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate. In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. The antiviral activities of tenofovir were first reported in 1993 and...
Experimental
Investigational
Matched Iupac: … ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid …
Matched Description: … available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain ... [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the ... [A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially …
Matched Categories: … Tenofovir and prodrugs …
Matched Description: … available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain ... [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the ... [A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially …
Matched Categories: … Tenofovir and prodrugs …
Polaprezinc
Polaprezinc is a chelated form of zinc and L-carnosine. It is a zinc-related medicine approved for the first time in Japan, which has been clinically used to treat gastric ulcers [L1307, L1308]. It was determined that polaprezinc may be effective in pressure ulcer treatment . A study in 2013 showed...
Experimental
Matched Iupac: … (4S)-3-(3-aminopropanoyl)-4-[(1H-imidazol-5-yl)methyl]-1-oxa-3-aza-2-zincacyclopentan-5-one …
Matched Description: … Polaprezinc is a chelated form of zinc and L-carnosine. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Polaprezinc is a chelated form of zinc and L-carnosine. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Molnupiravir
Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of N4-hydroxycytidine.[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed in vivo, and distributes into tissues where it becomes the active 5’-triphosphate form. The active drug incorporates into the genome of RNA viruses, leading to an accumulation of mutations known as...
Investigational
Matched Iupac: … 3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-(hydroxyimino)-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]oxolan-2-yl]methyl …
Matched Description: … distributes into tissues where it becomes the active 5’-triphosphate form. ... including SARS-CoV-2, in mice and human airway epithelial cells. ... A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo_, and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Description: … distributes into tissues where it becomes the active 5’-triphosphate form. ... including SARS-CoV-2, in mice and human airway epithelial cells. ... A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo_, and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Incadronic acid
Incadronate, or YM-175, is a nitrogen containing bisphosphonate. Along with being investigated to treat hypercalcemia of malignancy, it has also been investigated in the treatment of myeloma, leukemia, and other cancers.[A14426,A14431,A14427,A202769]
Incadronic acid was first described in the literature in 1991.
Experimental
Matched Iupac: … [(cycloheptylamino)(phosphono)methyl]phosphonic acid …
Matched Description: … hypercalcemia of malignancy,[A202862] it has also been investigated in the treatment of myeloma, leukemia, and …
Matched Description: … hypercalcemia of malignancy,[A202862] it has also been investigated in the treatment of myeloma, leukemia, and …
Mitoquinone
Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct...
Investigational
Matched Iupac: … [10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl]triphenylphosphanium …
Matched Description: … dysfunction also has been shown to represent an early critical event in the pathogenesis of the sporadic form ... Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate ... early-onset Parkinson's disease demonstrated a direct molecular link between mitochondrial dysfunction and …
Matched Categories: … Enzymes and Coenzymes …
Matched Description: … dysfunction also has been shown to represent an early critical event in the pathogenesis of the sporadic form ... Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate ... early-onset Parkinson's disease demonstrated a direct molecular link between mitochondrial dysfunction and …
Matched Categories: … Enzymes and Coenzymes …
(3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine
Experimental
Matched Iupac: … (2S,3R)-4-{[2-(3,4-dihydroxyphenyl)acetyl]oxy}-2-[(2-formylindolizin-3-yl)amino]-3-methyl-3-[(S)-sulfino …
Sulbutiamine
Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form a dimer. It is highly lipophilic, allowing it to cross the blood-brain barrier more easily than other thiamine derivatives. Although its clinical efficacy is not yet...
Experimental
Matched Iupac: … (3E)-4-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamido}-3-{[(2E)-2-{N-[(4-amino-2-methylpyrimidin ... -5-yl)methyl]formamido}-5-[(2-methylpropanoyl)oxy]pent-2-en-3-yl]disulfanyl}pent-3-en-1-yl 2-methylpropanoate …
Matched Description: … (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form ... While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural ... inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Description: … (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form ... While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural ... inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical …
Matched Categories: … Alimentary Tract and Metabolism …
Coenzyme A
Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of...
Investigational
Nutraceutical
Matched Iupac: … 2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl …
Matched Description: … enzymes use it, or a thioester form of it, as a substrate. ... of fatty acids, and the oxidation of pyruvate in the citric acid cycle. ... Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Description: … enzymes use it, or a thioester form of it, as a substrate. ... of fatty acids, and the oxidation of pyruvate in the citric acid cycle. ... Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Inecalcitol
Investigational
Matched Iupac: … (1R,3R)-5-{2-[(1R,3aR,4E,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-octahydro-1H-inden- …
Matched Categories: … Vitamin D and Analogues …
Matched Categories: … Vitamin D and Analogues …
Malacidin A
Malacidin A, along with DB14052, is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria . Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. While structurally similar to other macrocycle drugs like DB00080 and DB06087, Malacidin A...
Experimental
Matched Iupac: … (3S)-3-{[(4S,7R,10S,13S,16S,22R,25S,29R,30aS)-10-(4-aminobutyl)-13-[carboxy(hydroxy)methyl]-22-(1-carboxyethyl ... propan-2-yl)-triacontahydropyrrolo[2,1-c]1,4,7,10,13,16,19,22,25-nonaazacyclooctacosan-4-yl]carbamoyl}-2-methyl …
Matched Description: … While structurally similar to other macrocycle drugs like [DB00080] and [DB06087], Malacidin A appears ... Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … While structurally similar to other macrocycle drugs like [DB00080] and [DB06087], Malacidin A appears ... Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Malacidin B
Malacidin B, along with DB14051, is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria . Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. While structurally similar to other macrocycle drugs like DB00080 and DB06087, Malacidin B...
Experimental
Matched Iupac: … (3S)-3-{[(4S,7R,10S,13S,16S,22R,25S,29R,30aS)-10-(4-aminobutyl)-13-[carboxy(hydroxy)methyl]-22-(1-carboxyethyl ... propan-2-yl)-triacontahydropyrrolo[2,1-c]1,4,7,10,13,16,19,22,25-nonaazacyclooctacosan-4-yl]carbamoyl}-2-methyl …
Matched Description: … While structurally similar to other macrocycle drugs like [DB00080] and [DB06087], Malacidin B appears ... Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … While structurally similar to other macrocycle drugs like [DB00080] and [DB06087], Malacidin B appears ... Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Aldosterone
A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Experimental
Investigational
Matched Iupac: … (1S,3aS,3bS,9aR,9bS,10S,11aR)-10-hydroxy-1-(2-hydroxyacetyl)-9a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H …
Matched Description: … renal retention of sodium and the excretion of potassium. ... A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the …
Matched Categories: … Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … renal retention of sodium and the excretion of potassium. ... A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the …
Matched Categories: … Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Ularitide
Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Iupac: … ]-31,40-bis(3-carbamimidamidopropyl)-19-(2-carbamoylethyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22-methyl …
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... involved in regulating blood pressure and the excretion of water and sodium from the kidneys. ... Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... involved in regulating blood pressure and the excretion of water and sodium from the kidneys. ... Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Ifenprodil
N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer of dimers of both GluN1 and GluN2A-D subunits, with each subunit itself composed of an N-terminal domain (NTD), a ligand-binding...
Investigational
Withdrawn
Matched Description: … In addition, allosteric modulators are known to bind at the NTDs and form another layer of regulation ... N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family ... , with key roles in brain development and neurological function. …
Queuine
Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either...
Experimental
Nutraceutical
Matched Iupac: … (1R,2S,5S)-5-[({4-hydroxy-2-imino-1H,2H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}methyl)amino]cyclopent-3-ene- …
Matched Description: … and goats. ... plants and animals. ... Humans salvage and recover queuine from either ingested food or the gut flora. …
Matched Description: … and goats. ... plants and animals. ... Humans salvage and recover queuine from either ingested food or the gut flora. …
Nabiximols
Nabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species Cannabis sativa L. that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol). For trademark purposes, purified CBD is branded as Nabidiolex®, while THC is purified as the product Tetrabinex®. Sativex® is available in a...
Investigational
Matched Iupac: … (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol; 2-[(1R,6R)-3-methyl-6- …
Matched Description: … conditions, THC is currently commercially available in synthetic form as [DB00486], as purified isomer ... While cannabis in its natural plant form is currently used "off-label" for the management of many medical ... , and physiological effects. …
Matched Categories: … Cannabinoids and similars …
Matched Description: … conditions, THC is currently commercially available in synthetic form as [DB00486], as purified isomer ... While cannabis in its natural plant form is currently used "off-label" for the management of many medical ... , and physiological effects. …
Matched Categories: … Cannabinoids and similars …
Displaying drugs 351 - 375 of 375 in total