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Displaying drugs 576 - 600 of 661 in total

Tofisopam

Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor and its psychopharmacological profile differs from such compounds. Although Tofisopam is not approved...
Experimental
Matched Description: … benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid ... receptor and its psychopharmacological profile differs from such compounds. ... Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …

Refametinib

Investigational

Stibophen

Stibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms.
Experimental
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Alisertib

Alisertib is a novel aurora A kinase inhibitor under investigation for the treatment of various forms of cancer.
Investigational
Matched Iupac: … 3,5,9-triazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2,4,6,9,11,13-heptaen-4-yl]amino}-2-methoxybenzoic acid …
Matched Salts name: … Alisertib sodium …

Remogliflozin etabonate

Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.
Investigational
Matched Description: … Mellitus and Diabetes Mellitus, Type 2. ... Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes …
Matched Categories: … Sodium-Glucose Transporter 2 Inhibitors …

ATX-101

ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment for the reduction of localized fat deposits. This includes treatment of superficial lipomas (benign tumors of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and localized fat deposits in...
Investigational
Matched Description: … Deoxycholic acid is a naturally occurring bile acid produced by the liver as one of several end products ... ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment ... of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and …

Suramin

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin...
Investigational
Matched Iupac: … carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid …
Matched Description: … It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with …
Matched Salts name: … Suramin sodium …
Matched Categories: … suramin sodium ... Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …

Azimilide

Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.
Investigational
Matched Description: … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of …
Matched Categories: … Calcium-Regulating Hormones and Agents …

Ularitide

Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Iupac: … hydroxypropanamido]-3-phenylpropanamido]-5-carbamimidamidopentanamido]-3-(4-hydroxyphenyl)propanoic acid …
Matched Description: … the excretion of water and sodium from the kidneys. ... When injected into the blood, ularitide appears to cause diuresis (urine output) and natriuresis (sodium ... Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Vinbarbital

Experimental
Matched Salts name: … Vinbarbital sodium …
Matched Categories: … Hypnotics and Sedatives …

Pilsicainide

Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation.
Investigational
Matched Categories: … Sodium Channel Blockers …

Edetate copper disodium

Experimental

Enibomal

Experimental
Matched Salts name: … Enibomal sodium …

Glisoxepide

Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Matched Description: … However it inhibits taurocholate uptake only in the absence of sodium ions. ... transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and ... are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid …
Matched Categories: … Alimentary Tract and Metabolism …

Carbenoxolone

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. [PubChem]
Experimental
Matched Iupac: … 9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid …
Matched Categories: … Drugs for Acid Related Disorders ... Alimentary Tract and Metabolism ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Brequinar

Experimental
Matched Iupac: … 6-fluoro-2-{2'-fluoro-[1,1'-biphenyl]-4-yl}-3-methylquinoline-4-carboxylic acid …
Matched Salts name: … Brequinar sodium …

Cariporide

Investigational

Ethoxzolamide

Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.
Withdrawn
Matched Description: … Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. ... It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium …

Omapatrilat

Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating blood vessels, and reducing preload and ventricular remodeling. This drug from BMS was not approved by the FDA due...
Investigational
Matched Iupac: … -oxo-4-[(2S)-3-phenyl-2-sulfanylpropanamido]-octahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid …
Matched Description: … The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating ... blood vessels, and reducing preload and ventricular remodeling. ... Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin …

Methyclothiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Withdrawn
Matched Categories: … methyclothiazide and potassium ... Sodium Chloride Symporter Inhibitors …

Volixibat

Volixibat, also known as SHP626 or LUM002, is an investigational drug that will potentially be used for the treatment of Non-Alcoholic Steatohepatitis (NASH). If approved for use, it will be the first available agent for the treatment of NASH. Volixibat is a selective inhibitor of the apical sodium-dependent bile acid...
Experimental
Investigational
Matched Iupac: … tetrahydro-1lambda6-benzothiepin-5-yl]phenyl}carbamoyl)amino]-3,5-dihydroxyoxan-2-yl]methoxy}sulfonic acid …
Matched Description: … Volixibat is a selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT), a transmembrane ... Also known as the ileal bile acid transporter (IBAT), ASBT is primarily responsible for the enterohepatic ... recirculation of bile acids and ultimately for hepatic lipid and glucose metabolism [A32120]. …

Astodrimer

Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.
Investigational
Matched Description: … It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. ... Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. …
Matched Salts name: … Astodrimer Sodium …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Pirenoxine

Experimental
Matched Iupac: … 4-hydroxy-12-oxo-12H-10-oxa-1,5-diazatetraphene-2-carboxylic acid …
Matched Salts name: … Pirenoxine sodium …

Flomoxef

Flomoxef has been used in trials studying the treatment of Urinary Tract Infection.
Investigational
Matched Iupac: … 1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Salts name: … Flomoxef Sodium …

Danoprevir

Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.
Investigational
Matched Salts name: … Danoprevir sodium …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 576 - 600 of 661 in total