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Displaying drugs 76 - 100 of 8023 in total

Butabarbital

Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action...
Approved
Illicit
Matched Description: … Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other ... [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital …
Matched Categories: … combinations of barbiturates …

Benzthiazide

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat...
Approved
Matched Description: … Thiazides also cause loss of potassium and an increase in serum uric acid. …
Matched Categories: … combinations of sulfonamides …

Piretanide

Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups.
Approved
Matched Description: … using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of …
Matched Categories: … combinations of sulfonamides …

Eptotermin alfa

A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin alfa is an ingredient in the EMA-withdrawn product Osigraft.
Approved
Investigational
Withdrawn
Matched Description: … It is both a potent osteogenic factor and a specific regulator of nephrogenesis. …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Dibotermin alfa

Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Description: … Through enhancing osteogenesis at the site of implantation, dibotermin alfa accelerates the healing of ... In a prospective clinical study of patients with an open tibial fracture, administration of dibotermin ... BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Iophendylate

Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on...
Approved
Matched Description: … A number of clinicians have published on the dangers of oil myelography. ... In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified ... Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization …
Matched Categories: … Diagnostic Uses of Chemicals …

Zinc dibutyldithiocarbamate

Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. Sensitivity to zinc dibutyldithiocarbamate may be identified with a clinical patch test.
Approved
Experimental
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Gadopiclenol

Gadopiclenol is a gadolinium-based contrast agent (GBCA) based on a pyclen macrocyclic structure. It is indicated for use with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and the body. In 2006, the use of GBCAs was associated with the development...
Approved
Matched Description: … [L43817] In 2006, the use of GBCAs was associated with the development of nephrogenic systemic fibrosis ... [A254002,A254017] In September 2022, the use of gadopiclenol was approved by the FDA. ... (NSF), a rare disorder characterized by the thickening and hardening of skin and subcutaneous tissues …
Matched Categories: … Diagnostic Uses of Chemicals …

Zinc acetate

Approved
Investigational
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Viomycin

Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomycete Streptomyces puniceus.
Approved
Matched Categories: … Drugs for Treatment of Tuberculosis …

Ioflupane I-123

Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Iopodic acid

Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a...
Approved
Investigational
Withdrawn
Matched Description: … Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by ... [A32080] Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque …
Matched Categories: … Diagnostic Uses of Chemicals …

Iotrolan

Nonionic, isotonic contrast medium designed for intrathecal use.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Delamanid

Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall . It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen. Emergence of multidrug-resistant and extensively drug-resistant tuberculosis creates clinical challenges for...
Approved
Investigational
Matched Description: … that inhibits mycolic acid synthesis of bacterial cell wall [A31965]. ... Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds ... coenzymes responsible for bioactivation of delamanid contributes to this effect [L1407]. …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Piritramide

Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.
Approved
Investigational
Matched Description: … Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. ... Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Gefapixant

It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks. A subset of these patients remain symptomatic despite thorough investigation and treatment, termed refractory chronic cough (RCC) if they have a cough that does not respond...
Approved
Investigational
Matched Description: … It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a ... [L48601] A subset of these patients remain symptomatic despite thorough investigation and treatment, ... [L48596,L48591] It is the first therapy to be approved for the treatment of RCC or UCC in the EU. …
Matched Categories: … combinations of sulfonamides …

Acitretin

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Approved
Matched Description: … It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared ... An oral retinoid effective in the treatment of psoriasis. …
Matched Categories: … Retinoids for Treatment of Psoriasis …

Bacampicillin

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of...
Approved
Investigational
Matched Description: … the biosynthesis of cell wall mucopeptides. ... Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. ... is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of …
Matched Categories: … combinations of penicillins …

Pivampicillin

Pivalate ester analog of ampicillin.
Approved
Matched Description: … Pivalate ester analog of ampicillin. …
Matched Categories: … combinations of penicillins …

Normethadone

Normethadone is used as an opioid antitussive in combination with DB11610. It is marketed in Canada by Valeant under the tradename Cophylac.
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iomeprol

Iomeprol has been investigated for the diagnostic of Coronary Artery Disease.
Approved
Investigational
Matched Description: … Iomeprol has been investigated for the diagnostic of Coronary Artery Disease. …
Matched Categories: … Diagnostic Uses of Chemicals …

Eravacycline

Eravacycline, known as Xerava by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes most of those bacteria resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase inhibitors, multidrug-resistant strains, and carbapenem-resistant Enterobacteriaceae, and the majority of anaerobic...
Approved
Investigational
Matched Description: … Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of ... This includes most of those bacteria resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase ... Eravacycline has demonstrated superior potency to that of antibiotics that are currently being marketed …
Matched Categories: … combinations of tetracyclines …

Iobitridol

Iobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and Coronary Atherosclerosis.
Approved
Investigational
Matched Description: … Iobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease …
Matched Categories: … Diagnostic Uses of Chemicals …

Amitriptylinoxide

Amitriptylinoxide has been used in trials studying Major Depression.
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dexamethasone

Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was granted FDA approval on 30 October 1958....
Approved
Investigational
Vet approved
Matched Description: … [L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 …
Matched Mixtures name: … SONDEX-OF …
Matched Categories: … Inducers of Drug Clearance ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Displaying drugs 76 - 100 of 8023 in total