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Displaying drugs 101 - 125 of 418 in total
Clobetasone
Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
Approved
Matched Description: … as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and …
Matched Categories: … clobetasone and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … clobetasone and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Fosphenytoin
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Approved
Investigational
Matched Iupac: … [(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methoxy]phosphonic acid …
Matched Description: … channels, and therefore limit repetitive firing of action potentials. ... Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium …
Matched Categories: … Phenytoin and Prodrugs …
Matched Description: … channels, and therefore limit repetitive firing of action potentials. ... Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium …
Matched Categories: … Phenytoin and Prodrugs …
Carbamazepine
Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1....
Approved
Investigational
Matched Description: … and to treat pain resulting from trigeminal neuralgia. ... Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures …
Lonafarnib
Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cutaneous effects, lipoatrophy, alopecia, and a severe failure to thrive; HGPS is uniformly fatal.[A224379, A224384,...
Approved
Investigational
Matched Description: … treatment for HGPS and other related progeroid laminopathies. ... [A224379, A224414, A224419, L23414]
Merck originally developed Lonafarnib and subsequently licensed ... [L23414, L23544] Lonafarnib was granted FDA approval on November 20, 2020, and is the first FDA-approved …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Tenapanor
Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Iupac: … methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]benzenesulfonamido}ethoxy)ethoxy]ethyl}carbamoyl)amino]butyl}urea …
Matched Description: … [L8558] It was first designed and synthesized in 2012. ... currently only medication within its class[A185489,A185492,A185495] and therefore exists as a novel ... A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Description: … [L8558] It was first designed and synthesized in 2012. ... currently only medication within its class[A185489,A185492,A185495] and therefore exists as a novel ... A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and …
Matched Categories: … Alimentary Tract and Metabolism …
Capreomycin
Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.
Approved
Matched Categories: … Amino Acids, Peptides, and Proteins …
Dasabuvir
Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … [DB00503] for genotype 1b and with [DB00811] for genotype 1a of Hepatitis C [L852]. ... categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and …
Matched Categories: … dasabuvir, ombitasvir, paritaprevir and ritonavir …
Matched Categories: … dasabuvir, ombitasvir, paritaprevir and ritonavir …
Xamoterol
Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but has no agonist action on β2-adrenoceptors.
Approved
Matched Description: … Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function …
Trametinib
Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and ... [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission ... currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Viomycin
Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomycete Streptomyces puniceus.
Approved
Matched Description: … These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea
Experimental
Matched Name: … 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea …
Matched Iupac: … 3-(4-carbamimidoylphenyl)-1-(4-chlorophenyl)urea …
Matched Iupac: … 3-(4-carbamimidoylphenyl)-1-(4-chlorophenyl)urea …
1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea
Experimental
Matched Name: … 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea …
Matched Iupac: … 3-(4-carbamimidoylphenyl)-1-(4-phenoxyphenyl)urea …
Matched Iupac: … 3-(4-carbamimidoylphenyl)-1-(4-phenoxyphenyl)urea …
N-Cyclohexyl-N'-(Propyl)Phenyl Urea
Experimental
Matched Name: … N-Cyclohexyl-N'-(Propyl)Phenyl Urea …
Matched Iupac: … 1-cyclohexyl-3-(3-phenylpropyl)urea …
Matched Iupac: … 1-cyclohexyl-3-(3-phenylpropyl)urea …
N-Cyclohexyl-N'-(4-Iodophenyl)Urea
Experimental
Matched Name: … N-Cyclohexyl-N'-(4-Iodophenyl)Urea …
Matched Iupac: … 3-cyclohexyl-1-(4-iodophenyl)urea …
Matched Iupac: … 3-cyclohexyl-1-(4-iodophenyl)urea …
Orotic acid
Investigational
Matched Synonyms: … Orotic acid ... Uracil-6-carboxylic acid …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
N-acetyl-N'-beta-D-glucopyranosyl urea
Experimental
Matched Name: … N-acetyl-N'-beta-D-glucopyranosyl urea …
Matched Iupac: … 3-acetyl-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]urea …
Matched Iupac: … 3-acetyl-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]urea …
Uric acid
Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this...
Investigational
Matched Synonyms: … Lithic acid …
Matched Name: … Uric acid …
Matched Description: … As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and ... blood, called hyperuricemia, this can lead to gout and formation of kidney stones. ... as such, uric acid acts as an antioxidant. …
Matched Name: … Uric acid …
Matched Description: … As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and ... blood, called hyperuricemia, this can lead to gout and formation of kidney stones. ... as such, uric acid acts as an antioxidant. …
Orotidylic acid
Experimental
Matched Synonyms: … 6-carboxy-5'-uridylic acid …
Matched Name: … Orotidylic acid …
Matched Iupac: … -dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Name: … Orotidylic acid …
Matched Iupac: … -dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
Experimental
Matched Name: … N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA …
Matched Iupac: … 1-(2-chloro-4-fluorobenzoyl)-3-(5-hydroxy-2-methoxyphenyl)urea …
Matched Iupac: … 1-(2-chloro-4-fluorobenzoyl)-3-(5-hydroxy-2-methoxyphenyl)urea …
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Experimental
Matched Name: … 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA …
Matched Iupac: … 1-[4-(pyridin-4-yloxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea …
Matched Iupac: … 1-[4-(pyridin-4-yloxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea …
Dihydroorotic Acid
Experimental
Matched Name: … Dihydroorotic Acid …
Matched Iupac: … (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid …
Matched Iupac: … (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid …
UDP-alpha-D-glucuronic acid
A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones. [PubChem]
Experimental
Matched Synonyms: … UDP-Glucuronic Acid ... uridine diphosphate glucuronic acid ... Uridine-5'-diphosphate-glucuronic acid …
Matched Name: … UDP-alpha-D-glucuronic acid …
Matched Iupac: … dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid …
Matched Description: … It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. ... A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis ... In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Name: … UDP-alpha-D-glucuronic acid …
Matched Iupac: … dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid …
Matched Description: … It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. ... A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis ... In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
Experimental
Matched Name: … 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA …
Matched Iupac: … 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea …
Matched Iupac: … 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea …
1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
Experimental
Matched Name: … 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea …
Matched Iupac: … 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea …
Matched Iupac: … 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea …
N'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Urea
Experimental
Matched Name: … N'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Urea …
Matched Iupac: … 3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-(pyridin-2-yl)urea …
Matched Iupac: … 3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-(pyridin-2-yl)urea …
Displaying drugs 101 - 125 of 418 in total