Displaying all 3 drugs
Imipenem
Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits...
Approved
Matched Synonyms: … Imipenem ... Imipenem anhydrous …
Matched Name: … Imipenem …
Matched Description: … [A15389] Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug ... product with cilastatin and [relebactam] which was recently approved by the FDA. ... and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. …
Matched Mixtures name: … IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM ... Imipenem and Cilastatin …
Matched Salts name: … Imipenem monohydrate …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Matched Products: … Imipenem …
Matched Name: … Imipenem …
Matched Description: … [A15389] Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug ... product with cilastatin and [relebactam] which was recently approved by the FDA. ... and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. …
Matched Mixtures name: … IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM ... Imipenem and Cilastatin …
Matched Salts name: … Imipenem monohydrate …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Matched Products: … Imipenem …
Relebactam
Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to avibactam.[A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge. It is currently available in a combination product which includes imipenem and cilastatin to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated...
Approved
Investigational
Matched Description: … [A181207] It is currently available in a combination product which includes [imipenem] and [cilastatin ... ] to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated intra-abdominal ... [label] It is considered to be a last-line treatment option and gained FDA approval as part of the combination …
Matched Salts name: … Relebactam sodium …
Matched Categories: … imipenem, cilastatin and relebactam …
Matched Salts name: … Relebactam sodium …
Matched Categories: … imipenem, cilastatin and relebactam …
Cilastatin
Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of thienamycin beta-lactam antibiotics as well as conversion of leukotriene D4 to leukotriene E4. Since the antibiotic, imipenem, is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin is used in combination with imipenem to prevent...
Approved
Investigational
Matched Synonyms: … Cilastatin …
Matched Name: … Cilastatin …
Matched Description: … Since the antibiotic, [imipenem], is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin ... is used in combination with imipenem to prevent its metabolism. ... Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of …
Matched Mixtures name: … IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM ... Imipenem and Cilastatin …
Matched Salts name: … Cilastatin sodium …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Matched Products: … Cilastatin Sodium Sterile …
Matched Name: … Cilastatin …
Matched Description: … Since the antibiotic, [imipenem], is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin ... is used in combination with imipenem to prevent its metabolism. ... Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of …
Matched Mixtures name: … IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM ... Imipenem and Cilastatin …
Matched Salts name: … Cilastatin sodium …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Matched Products: … Cilastatin Sodium Sterile …
Displaying all 3 drugs