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Fibrinogen concentrate (human) is a hematological agent. It works by replacing a certain protein in the blood that helps with blood clotting. Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. It is a physiological substrate for three enzymes: plasmin, factor XIIIa and...
Approved
Matched Synonyms: … Fibrinogen human ... Fibrinogen (human) ... Human fibrinogen
Matched Name: … Fibrinogen human
Matched Description: … Fibrinogen concentrate (human) is a hematological agent. ... It is a physiological substrate for three enzymes: plasmin, factor XIIIa and thrombin. ... , including afibrinogenemia and hypofibrinogenemia. …
Matched Mixtures name: … EVICEL Fibrin Sealant (Human) ... EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml …
Matched Categories: … fibrinogen, human ... Fibrinogen ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … FIBRYGA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION OR INFUSION 1G/VIAL …
Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass...
Approved
Matched Synonyms: … Thrombin human ... Thrombin (human) ... Thrombin Human Plasma-derived …
Matched Name: … Human thrombin
Matched Description: … Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen ... Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation ... In particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin
Matched Mixtures name: … EVICEL Fibrin Sealant (Human) ... EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml …
Matched Products: … Thrombin Human
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Approved
Matched Synonyms: … Antithrombin III human ... Antithrombin III (human) ... Antithrombin III,human
Matched Name: … Antithrombin III human
Matched Description: … A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with platelets from the blood, forms a clot. Medical thrombin is a protein substance produced...
Approved
Investigational
Matched Synonyms: … Thrombin ... Thrombin bovine ... Thrombin, Topical (Bovine) …
Matched Name: … Thrombin
Matched Description: … A variety of human thrombin and recombinant thrombin (ie. thrombin alfa) products are available as alternatives ... These antibodies may subsequently cross-react with endogenous human factor V and lead to its deficiency ... Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with platelets …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... thrombin ... thrombin
Matched Products: … Thrombin-jmi …
Factor XIII (human) is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key...
Approved
Investigational
Matched Synonyms: … Factor XIII, human ... Human coagulation factor XIII ... Factor XIII concentrate (human) …
Matched Name: … Factor XIII (human) …
Matched Description: … When activated by thrombin at the site of injury, the FXIII pro-enzyme is cleaved resulting in activation ... Other drug products with similar structure and function to Factor XIII (human) include [DB09310], which ... Compared to Factor XIII (human), which is purified from pooled human plasma, [DB09310] is produced through …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Approved
Matched Name: … Coagulation factor VIIa Recombinant Human
Matched Description: … Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the ... Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … powder and solvent for solution for injection 2mg ... powder and solvent for solution for injection 1mg ... NOVOSEVEN 2MG POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to achieving hemostasis during surgery. ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from animal or human blood, as an aid to controlling bleeding during surgery. Thrombin is used in...
Approved
Investigational
Matched Synonyms: … Recombinant thrombin
Matched Description: … human blood proteins and in some cases these antibodies appear to be related to serious bleeding complications ... rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to ... ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from …
C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Synonyms: … Recombinant human C1 inhibitor ... Recombinant human C1-inhibitor ... Human C1-inhibitor (recombinant, rabbit derived) …
Matched Description: … C1 esterase inhibitor has also been shown to inhibit the action of thrombin within the coagulation pathway ... , and tPA and plasmin within the fibrinolytic pathway. ... Additionally, C4 and C2 cleavage occurs resulting in auto-activation of the complement system. …
Matched Categories: … Blood and Blood Forming Organs …
Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Synonyms: … Human factor VIII, recombinant B-domain deleted ... Antihemphilic factor, recombinant human B-domain deleted …
Matched Description: … , and as a result, leads to the conversion of fibrinogen to fibrin, the fibrous protein that creates ... purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which ... signals that results in activation of Factor X, which then results in the conversion of prothrombin to thrombin
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Description: … These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this ... The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor ... Susoctocog alfa was approved by the FDA in October 2014 and is marketed under the brand name Obizur for …
Matched Categories: … Blood and Blood Forming Organs …
Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and DB09301 , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity that works by inhibiting...
Approved
Withdrawn
Matched Description: … The active constituents are heparan, dermatan and [DB09301] [T28], and they are isolated from the porcine ... in the United States however it is available in several other countries including European countries and ... Danaproid is used in the treatment of heparin-induced thrombocytopenia (HIT) as an off-label indication and
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …
Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Description: … is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. ... conjugated molecule of rFVIII to polyethylene glycol is covalently fused to the dimeric Fc domain of human ... other hemorrhages that cause chronic pain and disability to patients [A31551, A31552]. …
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived ... It was developed by Novo Nordisk and approved by the US FDA on October 16, 2013 [L1104]. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet...
Approved
Matched Description: … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. ... Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated ... antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter …
Matched Categories: … Antacids and Adsorbents …
Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the...
Approved
Nutraceutical
Vet approved
Matched Description: … Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet ... d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and ... At the moment however, there exists a lack of formal data and evidence to support any such additional …
Matched Mixtures name: … Multi Vitamin and Mineral vitamin ... Iron With Vitamins C and E - Tab ... Vita Vim Multivitamins and Minerals Tab …
Protein S human is a vitamin K-dependent plasma glycoprotein which has antcoagulant properties . It serves as a negative feedback mechanism in the coagulation cascade.
Approved
Matched Synonyms: … Protein S (human) …
Matched Name: … Protein S human
Matched Description: … Protein S human is a vitamin K-dependent plasma glycoprotein which has antcoagulant properties [A19561 …
Matched Mixtures name: … OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for the management of bleeding in major surgery in patients with moderate and severe...
Approved
Investigational
Matched Synonyms: … Coagulation factor X (human) ... Human coagulation factor X …
Matched Name: … Coagulation factor X human
Matched Description: … Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and ... Coagulation Factor X (Human) solution is approved by the FDA for intravenous injection under the market ... children (aged 12 years and above) with hereditary Factor X deficiency. …
Matched Mixtures name: … OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Approved
Matched Synonyms: … Alfa 1-proteinase inhibitor (human) ... Alpha 1-proteinase inhibitor, human ... Alpha 1-proteinase inhibitor (human) …
Matched Description: … fractionation followed by PEG and zinc chloride fractionation. ... Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol …
Matched Categories: … Human alpha-1 Proteinase Inhibitor ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … Alpha1-proteinase Inhibitor (human) …
Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface...
Approved
Matched Synonyms: … Human protein C ... Protein C human ... Protein C concentrate human
Matched Description: … VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation. ... A lack of protein C in the body would lead to unchecked coagulation activation, resulting in thrombin ... It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Protein …
Matched Mixtures name: … OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism.
Approved
Investigational
Matched Synonyms: … Thrombomodulin (human 498-amino acid fragment) …
Matched Description: … It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential ... Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). ... treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism …
Matched Categories: … Receptors, Thrombin ... Amino Acids, Peptides, and Proteins …
Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential...
Approved
Matched Synonyms: … Blood Coagulation Factor XIII (Synthetic Human A-Chain Precursor) ... Human Factor XIII (A2) homodimer (allele F13A*1B), recombinant DNA origin …
Matched Description: … then isolated, the human form is isolated from pooled human plasma. ... When activated by thrombin at the site of injury, the FXIII A2B2 pro-enzyme is cleaved resulting in activation ... ) include [DB12909], which is a purified endogenous (human) form of coagulation factor XIII. …
Matched Categories: … Blood and Blood Forming Organs …
Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any...
Approved
Investigational
Matched Description: … Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human- or animal-derived ... [A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104] ... rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … NovoEight 500IU Powder and Solvent for Solution for Injection ... NovoEight 1000IU Powder and Solvent for Solution for Injection ... NovoEight® 250IU Powder and Solvent for Solution for Injection …
Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related platelet aggregation.
Approved
Matched Description: … By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related …
Matched Categories: … Blood and Blood Forming Organs ... Receptors, Thrombin, antagonists & inhibitors …
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide...
Approved
Matched Description: … Desirudin is a direct inhibitor of human thrombin. ... Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges ... include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and
Matched Categories: … Thrombin Inhibitors ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Coumarin derivative that acts as a long-acting oral anticoagulant.
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs …
Displaying drugs 1 - 25 of 41 in total