Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum.

Article Details

Citation

Takayama C, Inoue Y

Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum.

Neurosci Res. 2007 Feb;57(2):322-5. Epub 2006 Nov 28.

PubMed ID
17134779 [ View in PubMed
]
Abstract

Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl(-) concentration regulated by K(+)-Cl(-) co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Potassium chlorideSolute carrier family 12 member 5ProteinHumans
Unknown
Not AvailableDetails
Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
Potassium chlorideSolute carrier family 12 member 5ProteinHumans
Unknown
Substrate
Details