fMet-Leu-Phe receptor
Details
- Name
- fMet-Leu-Phe receptor
- Kind
- protein
- Synonyms
- fMLP receptor
- FPR
- N-formyl peptide receptor
- N-formylpeptide chemoattractant receptor
- Gene Name
- FPR1
- UniProtKB Entry
- P21462Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0016276|fMet-Leu-Phe receptor METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
- Number of residues
- 350
- Molecular Weight
- 38445.115
- Theoretical pI
- 9.46
- GO Classification
- FunctionsN-formyl peptide receptor activityProcesseschemotaxis / nitric oxide mediated signal transduction / signal transductionComponentsplasma membrane
- General Function
- High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:15153520, PubMed:15210802, PubMed:1712023, PubMed:2161213). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:10514456, PubMed:1712023). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802)
- Specific Function
- complement receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 28-50 62-83 101-121 141-162 206-226 243-266 286-305
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016277|fMet-Leu-Phe receptor (FPR1) ATGGAGACAAATTCCTCTCTCCCCACGAACATCTCTGGAGGGACACCTGCTGTATCTGCT GGCTATCTCTTCCTGGATATCATCACTTATCTGGTATTTGCAGTCACCTTTGTCCTCGGG GTCCTGGGCAACGGGCTTGTGATCTGGGTGGCTGGATTCCGGATGACACACACAGTCACC ACCATCAGTTACCTGAACCTGGCCGTGGCTGACTTCTGTTTCACCTCCACTTTGCCATTC TTCATGGTCAGGAAGGCCATGGGAGGACATTGGCCTTTCGGCTGGTTCCTGTGCAAATTC GTCTTTACCATAGTGGACATCAACTTGTTCGGAAGTGTCTTCCTGATCGCCCTCATTGCT CTGGACCGCTGTGTTTGCGTCCTGCATCCAGTCTGGACCCAGAACCACCGCACCGTGAGC CTGGCCAAGAAGGTGATCATTGGGCCCTGGGTGATGGCTCTGCTCCTCACATTGCCAGTT ATCATTCGTGTGACTACAGTACCTGGTAAAACGGGGACAGTAGCCTGCACTTTTAACTTT TCGCCCTGGACCAACGACCCTAAAGAGAGGATAAATGTGGCCGTTGCCATGTTGACGGTG AGAGGCATCATCCGGTTCATCATTGGCTTCAGCGCACCCATGTCCATCGTTGCTGTCAGT TATGGGCTTATTGCCACCAAGATCCACAAGCAAGGCTTGATTAAGTCCAGTCGTCCCTTA CGGGTCCTCTCCTTTGTCGCAGCAGCCTTTTTTCTCTGCTGGTCCCCATATCAGGTGGTG GCCCTTATAGCCACAGTCAGAATCCGTGAGTTATTGCAAGGCATGTACAAAGAAATTGGT ATTGCAGTGGATGTGACAAGTGCCCTGGCCTTCTTCAACAGCTGCCTCAACCCCATGCTC TATGTCTTCATGGGCCAGGACTTCCGGGAGAGGCTGATCCACGCCCTTCCCGCCAGTCTG GAGAGGGCCCTGACCGAGGACTCAACCCAAACCAGTGACACAGCTACCAATTCTACTTTA CCTTCTGCAGAGGTGGAGTTACAGGCAAAGTGA
- Chromosome Location
- 19
- Locus
- 19q13.41
- External Identifiers
Resource Link UniProtKB ID P21462 UniProtKB Entry Name FPR1_HUMAN GenBank Protein ID 189184 GenBank Gene ID M37128 GeneCard ID FPR1 GenAtlas ID FPR1 HGNC ID HGNC:3826 PDB ID(s) 7EUO, 7T6T, 7VFX, 7WVU KEGG ID hsa:2357 IUPHAR/Guide To Pharmacology ID 222 NCBI Gene ID 2357 - General References
- Boulay F, Tardif M, Brouchon L, Vignais P: Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun. 1990 May 16;168(3):1103-9. [Article]
- Boulay F, Tardif M, Brouchon L, Vignais P: The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry. 1990 Dec 18;29(50):11123-33. [Article]
- Murphy PM, McDermott D: Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. J Biol Chem. 1991 Jul 5;266(19):12560-7. [Article]
- Bao L, Gerard NP, Eddy RL Jr, Shows TB, Gerard C: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics. 1992 Jun;13(2):437-40. [Article]
- Murphy PM, Tiffany HL, McDermott D, Ahuja SK: Sequence and organization of the human N-formyl peptide receptor-encoding gene. Gene. 1993 Nov 15;133(2):285-90. [Article]
- Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Perez HD, Holmes R, Kelly E, McClary J, Chou Q, Andrews WH: Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. Biochemistry. 1992 Nov 24;31(46):11595-9. [Article]
- Maestes DC, Potter RM, Prossnitz ER: Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J Biol Chem. 1999 Oct 15;274(42):29791-5. [Article]
- Postma B, Poppelier MJ, van Galen JC, Prossnitz ER, van Strijp JA, de Haas CJ, van Kessel KP: Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. J Immunol. 2004 Jun 1;172(11):6994-7001. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nedocromil approved, investigational unknown target antagonist Details Rebamipide approved, investigational yes target antagonist Details