ATP-dependent Clp protease ATP-binding subunit ClpX
Details
- Name
- ATP-dependent Clp protease ATP-binding subunit ClpX
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- clpX
- UniProtKB Entry
- O25926Swiss-Prot
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- NCBI Taxonomy ID
- 85962
- Amino acid sequence
>lcl|BSEQ0012159|ATP-dependent Clp protease ATP-binding subunit ClpX MNETLYCSFCKKPESRDPKKRRIIFASNLNKDVCVCEYCIDVMHGELHKYDNSLLALKRD RLRRMESSAYEEEFLLSYIPAPKELKAVLDNYVIGQEQAKKVFSVAVYNHYKRLSFKEKL KKQDNQDSNVELEHLEEVELSKSNILLIGPTGSGKTLMAQTLAKHLDIPIAISDATSLTE AGYVGEDVENILTRLLQASDWNVQKAQKGIVFIDEIDKISRLSENRSITRDVSGEGVQQA LLKIVEGSLVNIPPKGGRKHPEGNFIQIDTSDILFICAGAFDGLAEIIKKRTTQNVLGFT QEKMSKKEQEAILHLVQTHDLVTYGLIPELIGRLPVLSTLDSISLEAMVDILQKPKNALI KQYQQLFKMDEVDLIFEEEAIKEIAQLALERKTGARGLRAIIEDFCLDIMFDLPKLKGSE VRITKDCVLKQAEPLIIAKTHSKILP
- Number of residues
- 446
- Molecular Weight
- 50352.815
- Theoretical pI
- 6.44
- GO Classification
- FunctionsATP binding / zinc ion bindingProcessesprotein folding
- General Function
- ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012160|ATP-dependent Clp protease ATP-binding subunit ClpX (clpX) ATGAACGAAACGCTTTATTGCAGTTTTTGCAAAAAACCAGAATCAAGAGATCCCAAAAAA CGCCGCATTATTTTTGCGAGCAATCTCAATAAAGATGTGTGCGTGTGCGAATATTGTATA GATGTGATGCATGGGGAATTGCACAAATACGACAATTCTTTATTGGCGCTCAAAAGAGAC CGATTGAGAAGAATGGAATCTAGCGCTTATGAAGAAGAGTTTTTACTCTCTTACATTCCA GCCCCTAAAGAGCTTAAGGCGGTTTTAGACAATTATGTGATAGGGCAAGAGCAGGCTAAA AAGGTTTTTTCCGTAGCCGTGTATAACCATTACAAACGCTTATCTTTTAAAGAAAAACTC AAAAAACAAGACAACCAAGACAGCAATGTGGAGTTAGAGCATTTAGAAGAAGTGGAGTTG AGCAAGTCTAATATTTTACTAATCGGCCCTACAGGATCAGGCAAAACTTTAATGGCGCAA ACTCTGGCCAAGCATTTGGATATTCCTATCGCCATTAGCGATGCGACTAGCTTGACTGAA GCGGGCTATGTGGGCGAAGACGTGGAAAATATTCTCACAAGATTGTTGCAAGCGAGCGAC TGGAATGTCCAAAAAGCCCAAAAAGGCATTGTGTTTATTGATGAGATTGATAAAATCAGC CGTTTGTCAGAAAACCGCTCTATCACTAGAGATGTTTCTGGCGAGGGCGTTCAGCAAGCG TTGTTGAAAATCGTTGAAGGTTCTTTAGTGAATATCCCCCCCAAAGGCGGCAGAAAGCAC CCTGAGGGCAATTTCATTCAAATTGACACGAGCGATATTTTATTCATTTGTGCTGGAGCG TTTGATGGGTTAGCTGAAATCATTAAAAAACGCACCACGCAGAATGTGTTGGGTTTCACT CAAGAAAAGATGAGCAAAAAAGAGCAAGAAGCGATCTTGCATTTAGTCCAAACCCATGAC CTGGTTACTTATGGGCTTATCCCTGAGCTTATTGGCCGTTTGCCGGTTTTAAGCACGCTA GATAGCATCAGTTTAGAAGCGATGGTGGATATTTTACAAAAACCTAAAAACGCTCTTATC AAGCAATACCAGCAGCTTTTCAAAATGGATGAGGTGGATTTGATCTTTGAAGAAGAAGCC ATTAAAGAAATCGCTCAACTCGCATTAGAAAGAAAAACCGGGGCTAGGGGCTTAAGGGCG ATCATTGAAGATTTTTGTTTGGATATTATGTTTGATTTACCCAAGCTTAAAGGATCGGAA GTGCGTATCACTAAAGATTGTGTTTTAAAACAGGCTGAACCTTTGATCATTGCTAAAACG CATTCTAAAATTCTTCCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O25926 UniProtKB Entry Name CLPX_HELPY GenBank Gene ID AE000511 PDB ID(s) 1UM8 KEGG ID heo:C694_07090 NCBI Gene ID 900311 - General References
- Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
- Kim DY, Kim KK: Crystal structure of ClpX molecular chaperone from Helicobacter pylori. J Biol Chem. 2003 Dec 12;278(50):50664-70. Epub 2003 Sep 26. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Bismuth subcitrate potassium approved, investigational unknown target antagonist Details