Tubulin monoglycylase TTLL3

Details

Name
Tubulin monoglycylase TTLL3
Kind
protein
Synonyms
  • 6.3.2.-
  • HOTTL
  • Tubulin--tyrosine ligase-like protein 3
Gene Name
TTLL3
UniProtKB Entry
Q9Y4R7Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049726|Tubulin monoglycylase TTLL3
MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLD
SSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDE
VDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQ
PKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQRYYQV
VHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLE
EMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIR
FSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAW
STIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPST
AVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKK
PMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLV
GTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLC
PLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKL
GKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGSTARA
Number of residues
772
Molecular Weight
87413.395
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / protein-glycine ligase activity / protein-glycine ligase activity, initiating
Processes
axoneme assembly / cilium assembly
Components
axoneme / cilium / microtubule / microtubule cytoskeleton
General Function
Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (By similarity). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development (PubMed:25180231). Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (By similarity)
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton
Gene sequence
>lcl|BSEQ0049727|Tubulin monoglycylase TTLL3 (TTLL3)
ATGCAGGGCCCCGACGCGCCACTGCTCCTGAGCGCGAGGGAGCTGGGGCCCGGGCGCCGG
GGCTCGGCCTCCTGGTACCGCCAGGAGGGCGGCGCGGTGTGCAACTGGCTGCGGAAGCCG
CAGCCGCTCGAGCCACGCACCAGTTTCCCCTCGGCGCGCCGCTCCGAGTTCCGTCCACCC
AGGAGGCTGCCATGGGCCGGCCCTGCCTCCGCCCAGTCCGAGGAGGGTCACGCAGGCGGC
AGATGCCAGGCGGGCAGCCCCGCCCCTGCGCGCCGCCTCAGCGGCGCCTTCAAGACGCTG
GTCCCAGGCACCCACGCCCAGGGCGCCTCGGATACCCACCCCCTCGGCCCCCCGCACACC
CCGGTCCTCGACCCCTCTCCGCAGGATGGTTTCCCGGTCCTCTGGCGAGGATCCTCCAAG
GCGTCTCACATGAACCGGCTCAGAAACGCCAAAATCTACGTGGAGAGAGCTGTCAAGCAG
AAGAAGATCTTTACAATCCAAGGCTGCTACCCGGTGATCCGGTGTCTCTTGCGCCGGAGG
GGCTGGGTGGAGAAGAAGATGGTCCATCGCTCAGGCCCCACCCTGCTGCCACCCCAGAAG
GATCTGGATAGCTCAGCGATGGGTGACAGTGACACCACTGAGGATGAGGATGAAGATGAG
GACGAGGAGTTCCAGCCATCACAGCTGTTCGACTTCGATGATTTACTGAAATTTGATGAC
CTAGATGGAACACATGCTCTGATGGTGGGTCTATGTCTCAATCTCCGGAATTTGCCGTGG
TTTGATGAGGTTGATGCCAACTCCTTCTTCCCACGCTGCTACTGCCTGGGGGCTGAGGAT
GACAAAAAAGCCTTCATAGAGGACTTCTGGCTGACTGCTGCCCGCAACGTTCTCAAGCTG
GTGGTGAAGTCTGAGTGGAAGTCATACCCTATTCAGGCAGTAGAGGAAGAGGCCTCAGGA
GACAAGCAGCCCAAGAAACAGGAGAAAAACCCAGTGTTGGTGTCCCCAGAGTTTGTGGAT
GAAGCTCTGTGTGCGTGCGAGGAGTACCTTAGCAACTTGGCCCACATGGACATCGACAAG
GACCTGGAGGCCCCGCTGTACCTCACCCCCGAGGGCTGGTCCCTCTTCCTCCAGCGCTAC
TACCAAGTGGTCCACGAAGGGGCAGAACTCAGGCACCTCGACACTCAGGTCCAGCGCTGT
GAGGACATCCTGCAGCAGCTGCAGGCCGTGGTACCCCAGATAGACATGGAAGGGGATCGC
AACATCTGGATCGTGAAGCCAGGAGCCAAGTCCCGCGGACGAGGCATCATGTGCATGGAC
CACCTGGAGGAGATGCTGAAGCTGGTGAACGGCAACCCCGTGGTGATGAAGGACGGCAAG
TGGGTGGTGCAGAAGTATATTGAGCGGCCCCTCCTCATCTTTGGCACCAAGTTTGACCTC
AGACAGTGGTTCCTGGTAACTGACTGGAACCCACTTACCGTGTGGTTCTACCGCGACAGC
TATATCCGCTTTTCCACGCAGCCCTTCTCCCTGAAGAACCTGGACAACTCAGTGCACCTG
TGCAACAACTCCATCCAGAAGCACCTGGAGAACTCATGCCATCGGCATCCACTGCTTCCG
CCAGACAACATGTGGTCTAGCCAGAGGTTCCAGGCCCACCTGCAGGAGATGGGTGCCCCA
AATGCTTGGTCCACCATCATCGTGCCTGGCATGAAGGATGCTGTGATCCACGCACTTCAG
ACCTCCCAGGACACCGTGCAGTGTCGGAAGGCCAGCTTTGAGCTCTATGGCGCTGACTTC
GTGTTCGGGGAGGACTTCCAGCCCTGGCTGATTGAGATCAACGCCAGCCCCACGATGGCA
CCCTCCACAGCAGTCACTGCCCGGCTCTGTGCTGGCGTGCAAGCTGACACCCTGCGCGTG
GTCATTGACCGGATGCTGGACCGCAACTGTGACACAGGAGCCTTTGAGCTCATCTATAAG
CAGCCTGCTGTGGAGGTGCCTCAATATGTGGGCATCCGGCTCCTGGTAGAGGGCTTCACC
ATCAAGAAGCCCATGGCGATGTGTCATCGGCGGATGGGGGTCCGCCCAGCAGTCCCTCTG
CTGACCCAGCGAGGCTCTGGGGAAGCCCGTCACCACTTCCCCAGCCTCCACACCAAGGCC
CAGCTGCCTTCTCCCCATGTACTCCGACACCAGGGCCAGGTCCTCAGACGACAGCACAGC
AAGCTGGTGGGCACTAAGGCCCTGTCGACCACAGGCAAGGCCTTGAGGACTCTACCCACG
GCTAAGGTCTTCATTTCCCTCCCACCGAACCTTGATTTCAAGGTGGCACCCAGCATCCTG
AAGCCAAGAAAGGCTCCTGCTCTCCTGTGCCTCCGAGGCCCCCAGCTGGAAGTGCCTTGT
TGCCTCTGCCCTTTGAAGTCGGAACAATTCCTAGCACCTGTCGGAAGGTCAAGGCCAAAG
GCAAATTCAAGGCCAGACTGTGACAAACCCAGGGCTGAGGCCTGCCCCATGAAGAGGCTG
AGCCCCCTGAAACCCCTGCCCCTTGTTGGTACATTCCAGAGGCGCAGGGGCCTGGGGGAT
ATGAAGCTAGGGAAGCCCCTGCTTCGATTCCCCACTGCCCTTGTCCTGGATCCAACACCA
AATAAAAAGAAACAAGTGAAGTATTTGGGGCTTGACTCCATTGCTGTTGGAGGGTCAAGA
GTGGATGGGGCGAGGCCGTGTACCCCAGGGTCCACAGCAAGAGCCTGA
Chromosome Location
3
Locus
3p25.3
External Identifiers
ResourceLink
UniProtKB IDQ9Y4R7
UniProtKB Entry NameTTLL3_HUMAN
GeneCard IDTTLL3
HGNC IDHGNC:24483
KEGG IDhsa:26140
NCBI Gene ID26140
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
TheophyllineapprovedunknowntargetDetails