5-hydroxytryptamine receptor 3D
Details
- Name
- 5-hydroxytryptamine receptor 3D
- Kind
- protein
- Synonyms
- 5-HT3-D
- 5-HT3D
- Serotonin receptor 3D
- Gene Name
- HTR3D
- UniProtKB Entry
- Q70Z44Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008662|5-hydroxytryptamine receptor 3D MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPAAFQAVFDRKAIGPVTNYS VATHVNISFTLSAIWNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLS DVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMSRS FQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPS GILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALM QTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCP TAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVE LWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
- Number of residues
- 454
- Molecular Weight
- 50190.625
- Theoretical pI
- Not Available
- GO Classification
- Processesserotonin receptor signaling pathwayComponentsneuron projection / plasma membrane / synapse
- General Function
- Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
- Specific Function
- excitatory extracellular ligand-gated monoatomic ion channel activity
- Pfam Domain Function
- Signal Regions
- 1-24
- Transmembrane Regions
- 233-253 265-285 307-327 432-452
- Cellular Location
- Postsynaptic cell membrane
- Gene sequence
>lcl|BSEQ0013339|5-hydroxytryptamine receptor 3D (HTR3D) ATGGAAAGAGGCTGGTTCCATGGGAAAGGATTCCTCCTTGGCTTCATCCTCCACCTGCTG CTGCAAGATTCACACCTTCAACTGGTGACATCGTTCCTGTGGCTAAATATGTGGAACCCA GATGAATGCGGAGGCATCAAGAAGTCCGGCATGGCAACTGAGAACCTATGGCTTTCAGAT GTCTTCATCGAGGAGTCTGTGGATCAGACACCTGCAGGTCTCATGGCTAGTATGTCAATA GTGAAGGCCACATCAAACACAATAAGCCAATGTGGGTGGTCAGCATCTGCAAACTGGACA CCTTCTATTTCCCCTTCCATGGACAGAGGTGAACGCTCTCCTTCAGCCCTTTCACCTACA CAGGTAACCCGGGCATGGAGAAGGATGTCCAGGAGCTTTCAAATACATCACAGAACCTCA TTCAGAACAAGGAGGGAGTGGGTACTGCTGGGTATCCAAAAAAGAACAATAAAGGTGACC GTGGCCACTAACCAGTATGAACAAGCCATCTTCCATGTGGCCATCAGGCGCAGGTGCAGG CCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCC CTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTG CTGGGCTACAGCGTCTTCCTGCTCATGATGAATGACTTGCTCCCAGCCACTAGCACTTCA TCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTC GCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTG CTGCACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTG CACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCG GGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATG CCAGGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAA CACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGAC GCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGC CTCTGGAACACCTAG
- Chromosome Location
- 3
- Locus
- 3q27.1
- External Identifiers
Resource Link UniProtKB ID Q70Z44 UniProtKB Entry Name 5HT3D_HUMAN GeneCard ID HTR3D HGNC ID HGNC:24004 KEGG ID hsa:200909 NCBI Gene ID 200909 - General References
- Niesler B, Frank B, Kapeller J, Rappold GA: Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene. 2003 May 22;310:101-11. [Article]
- Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, Bonisch H, Gothert M, Rappold G, Bruss M: Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol. 2007 Jul;72(1):8-17. Epub 2007 Mar 28. [Article]
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