Cytochrome P-450 CYP3A5 Inhibitors (weak)

Name
Cytochrome P-450 CYP3A5 Inhibitors (weak)
Accession Number
DBCAT004488
Description

Not Available

Drugs
DrugDrug Description
AcalabrutinibA Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.
IndinavirA protease inhibitor used to treat HIV infection.
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
AmlodipineA calcium channel blocker used to treat hypertension and angina.
OsilodrostatAn oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DronabinolA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
CannabinolCannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa.
OlaparibA poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.
IvacaftorA cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication.
Drugs & Drug Targets
DrugTargetType
AcalabrutinibTyrosine-protein kinase BTKtarget
AcalabrutinibCytochrome P450 3A4enzyme
AcalabrutinibCytochrome P450 3A5enzyme
AcalabrutinibCytochrome P450 3A Subfamilyenzyme
AcalabrutinibAlbumincarrier
Acalabrutinibalpha1-acid glycoproteincarrier
IndinavirPol polyproteintarget
IndinavirCytochrome P450 3A4enzyme
IndinavirCytochrome P450 3A5enzyme
IndinavirCytochrome P450 3A7enzyme
IndinavirATP-dependent translocase ABCB1transporter
IndinavirSolute carrier family 22 member 1transporter
IndinavirMultidrug resistance-associated protein 1transporter
IndinavirSolute carrier organic anion transporter family member 1A2transporter
IndinavirSolute carrier organic anion transporter family member 1B1transporter
IndinavirATP-binding cassette sub-family C member 2transporter
IndinavirCytochrome P450 2D6enzyme
IndinavirUDP-glucuronosyltransferase 1A1enzyme
IndinavirSolute carrier organic anion transporter family member 2B1transporter
IndinavirBile salt export pumptransporter
IndinavirGag-Pol polyproteintarget
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 2C19enzyme
FluconazoleATP-dependent translocase ABCB1transporter
FluconazoleLanosterol 14-alpha demethylasetarget
FluconazoleCytochrome P450 3A5enzyme
AmlodipineCarbonic anhydrase 1target
AmlodipineCytochrome P450 3A4enzyme
AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
AmlodipineCytochrome P450 1A1enzyme
AmlodipineCytochrome P450 2B6enzyme
AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
AmlodipineCytochrome P450 3A5enzyme
AmlodipineATP-dependent translocase ABCB1transporter
AmlodipineCytochrome P450 2C8enzyme
AmlodipineCytochrome P450 2D6enzyme
AmlodipineSphingomyelin phosphodiesterasetarget
AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
AmlodipineVoltage-dependent N-type calcium channeltarget
AmlodipineCytochrome P450 2C19enzyme
AmlodipineCytochrome P450 2C9enzyme
AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
OsilodrostatCytochrome P450 11B1, mitochondrialtarget
OsilodrostatCytochrome P450 11B2, mitochondrialtarget
OsilodrostatCytochrome P450 3A4enzyme
OsilodrostatCytochrome P450 2B6enzyme
OsilodrostatCytochrome P450 2D6enzyme
OsilodrostatUDP-glucuronosyltransferase 1A4enzyme
OsilodrostatUDP-glucuronosyltransferase 2B7enzyme
OsilodrostatUDP-glucuronosyltransferase 2B10enzyme
OsilodrostatCytochrome P450 3A5enzyme
OsilodrostatCytochrome P450 1A2enzyme
OsilodrostatCytochrome P450 2C19enzyme
OsilodrostatCytochrome P450 2E1enzyme
OsilodrostatSolute carrier organic anion transporter family member 1B1transporter
OsilodrostatSolute carrier family 22 member 1transporter
OsilodrostatSolute carrier family 22 member 2transporter
OsilodrostatSolute carrier family 22 member 6transporter
OsilodrostatOrganic anion transporter 3transporter
OsilodrostatMultidrug and toxin extrusion protein 1transporter
OsilodrostatUDP-glucuronosyltransferase 1A1enzyme
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineATP-dependent translocase ABCB1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineOrganic cation/carnitine transporter 2transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineOrganic anion transporter 3transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineFlavin-containing monooxygenase 3enzyme
CimetidineFlavin-containing monooxygenase 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
CimetidineAlbumincarrier
DronabinolCannabinoid receptor 1target
DronabinolCytochrome P450 3A4enzyme
DronabinolCytochrome P450 2C9enzyme
DronabinolCannabinoid receptor 2target
DronabinolATP-dependent translocase ABCB1transporter
DronabinolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DronabinolProstaglandin G/H synthase 1enzyme
DronabinolCytochrome P450 2C19enzyme
DronabinolCytochrome P450 1A1enzyme
DronabinolCytochrome P450 1A2enzyme
DronabinolCytochrome P450 1B1enzyme
DronabinolCytochrome P450 2A6enzyme
DronabinolCytochrome P450 2B6enzyme
DronabinolCytochrome P450 2D6enzyme
DronabinolCytochrome P450 2J2enzyme
DronabinolCytochrome P450 3A5enzyme
DronabinolCytochrome P450 3A7enzyme
DronabinolMultidrug resistance-associated protein 1transporter
DronabinolLiver carboxylesterase 1enzyme
DronabinolUDP-glucuronosyltransferase 1A1enzyme
DronabinolUDP-glucuronosyltransferase 1A3enzyme
DronabinolUDP-glucuronosyltransferase 1A9enzyme
DronabinolUDP-glucuronosyltransferase 1A10enzyme
CannabinolCytochrome P450 3A4enzyme
CannabinolCytochrome P450 2C19enzyme
CannabinolCytochrome P450 1A1enzyme
CannabinolCytochrome P450 1A2enzyme
CannabinolCytochrome P450 1B1enzyme
CannabinolCytochrome P450 2A6enzyme
CannabinolCytochrome P450 2B6enzyme
CannabinolCytochrome P450 2C9enzyme
CannabinolCytochrome P450 2D6enzyme
CannabinolCytochrome P450 3A5enzyme
CannabinolCytochrome P450 3A7enzyme
CannabinolUDP-glucuronosyltransferase 1A7enzyme
CannabinolUDP-glucuronosyltransferase 1A8enzyme
CannabinolUDP-glucuronosyltransferase 1A9enzyme
CannabinolUDP-glucuronosyltransferase 1A10enzyme
CannabinolUDP-glucuronosyltransferase 2B7enzyme
CannabinolATP-dependent translocase ABCB1transporter
CannabinolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CannabinolMultidrug resistance-associated protein 1transporter
CannabinolCytochrome P450 2E1enzyme
CannabinolCytochrome P450 2J2enzyme
CannabinolLiver carboxylesterase 1enzyme
CannabinolCannabinoid receptor 1target
OlaparibPoly [ADP-ribose] polymerase 1target
OlaparibCytochrome P450 3A4enzyme
OlaparibCytochrome P450 2B6enzyme
OlaparibPoly [ADP-ribose] polymerase 2target
OlaparibProtein mono-ADP-ribosyltransferase PARP3target
OlaparibCytochrome P450 3A5enzyme
OlaparibATP-dependent translocase ABCB1transporter
OlaparibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
OlaparibAldo-keto reductase family 1 member C3target
OlaparibUDP-glucuronosyltransferase 1A1enzyme
OlaparibAlbumincarrier
OlaparibAlpha-1-acid glycoprotein 1carrier
IvacaftorCystic fibrosis transmembrane conductance regulatortarget
IvacaftorCytochrome P450 3A4enzyme
IvacaftorAlbumincarrier
IvacaftorAlpha-1-acid glycoprotein 1carrier
IvacaftorATP-dependent translocase ABCB1transporter
IvacaftorCytochrome P450 3A5enzyme
IvacaftorCytochrome P450 2C9enzyme