Bruton's tyrosine kinase (BTK) inhibitors

Name
Bruton's tyrosine kinase (BTK) inhibitors
Accession Number
DBCAT005749
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
AcalabrutinibA Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.
ZanubrutinibA kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.
PirtobrutinibA kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
OrelabrutinibOrelabrutinib is under investigation in clinical trial NCT04305197 (A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE)).
Drugs & Drug Targets
DrugTargetType
IbrutinibTyrosine-protein kinase BTKtarget
IbrutinibCytochrome P450 3A4enzyme
IbrutinibCytochrome P450 3A5enzyme
IbrutinibAlbumincarrier
Ibrutinibalpha1-acid glycoproteincarrier
IbrutinibCytochrome P450 2D6enzyme
AcalabrutinibTyrosine-protein kinase BTKtarget
AcalabrutinibCytochrome P450 3A4enzyme
AcalabrutinibCytochrome P450 3A5enzyme
AcalabrutinibCytochrome P450 3A Subfamilyenzyme
AcalabrutinibAlbumincarrier
Acalabrutinibalpha1-acid glycoproteincarrier
ZanubrutinibCytochrome P450 3A4enzyme
ZanubrutinibATP-dependent translocase ABCB1transporter
ZanubrutinibCytochrome P450 2B6enzyme
ZanubrutinibTyrosine-protein kinase BTKtarget
ZanubrutinibEpidermal growth factor receptortarget
ZanubrutinibReceptor tyrosine-protein kinase erbB-2target
ZanubrutinibReceptor tyrosine-protein kinase erbB-4target
ZanubrutinibTyrosine-protein kinase ITK/TSKtarget
ZanubrutinibCytoplasmic tyrosine-protein kinase BMXtarget
ZanubrutinibTyrosine-protein kinase JAK2target
ZanubrutinibTyrosine-protein kinase Tectarget
ZanubrutinibTyrosine-protein kinase Blktarget
ZanubrutinibTyrosine-protein kinase JAK3target
ZanubrutinibProtein-tyrosine kinase 6target
ZanubrutinibTyrosine-protein kinase Fgrtarget
ZanubrutinibTyrosine-protein kinase FRKtarget
ZanubrutinibTyrosine-protein kinase Lcktarget
ZanubrutinibTyrosine-protein kinase TXKtarget
ZanubrutinibCytochrome P450 3A Subfamilyenzyme
PirtobrutinibCytochrome P450 3A4enzyme
PirtobrutinibUDP-glucuronosyltransferase 1A8enzyme
PirtobrutinibUDP-glucuronosyltransferase 1A9enzyme
PirtobrutinibCytochrome P450 2C8enzyme
PirtobrutinibCytochrome P450 2C9enzyme
PirtobrutinibCytochrome P450 1A2enzyme
PirtobrutinibCytochrome P450 2B6enzyme
PirtobrutinibCytochrome P450 2C19enzyme
PirtobrutinibCytochrome P450 2D6enzyme
PirtobrutinibCytochrome P450 3A5enzyme
PirtobrutinibTyrosine-protein kinase BTKtarget
PirtobrutinibATP-dependent translocase ABCB1transporter
PirtobrutinibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
OrelabrutinibTyrosine-protein kinase BTKtarget