Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen

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Data Packages

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Identification

Brand Names

Capvaxive, Prevnar 13, Prevnar 20, Vaxneuvance

Generic Name

Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen

DrugBank Accession Number

DB10294

Background

Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 3 individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Type

Biotech

Groups

Approved

Biologic Classification

Vaccines
Conjugate

Synonyms

• Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine

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Pharmacology

Indication

Not Available

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Used in combination to prevent	Invasive streptococcal infection	Combination Product in combination with: Streptococcus pneumoniae type 31 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19351), Streptococcus pneumoniae type 16F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19345), Streptococcus pneumoniae type 24F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19350), Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16711), Streptococcus pneumoniae type 23B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19349), Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16714), Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10297), Streptococcus pneumoniae type 23A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19348), Streptococcus pneumoniae type 35B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19352), Streptococcus pneumoniae type 8 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16713), Streptococcus pneumoniae type 20A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19347), Streptococcus pneumoniae type deOAc15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19344), Streptococcus pneumoniae type 9N capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19342), Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10296), Streptococcus pneumoniae type 15A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19343), Streptococcus pneumoniae type 11A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16715), Streptococcus pneumoniae type 17F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19346), Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16710), Corynebacterium diphtheriae CRM197 protein (DB16712), Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10298), Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16716)	••••••••••••			•••••••••• ••••••••
Used in combination to prevent	Streptococcal pneumonia	Combination Product in combination with: Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16714), Corynebacterium diphtheriae CRM197 protein (DB16712), Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16716), Streptococcus pneumoniae type 23A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19348), Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16710), Streptococcus pneumoniae type 35B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19352), Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10298), Streptococcus pneumoniae type 17F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19346), Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10296), Streptococcus pneumoniae type 8 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16713), Streptococcus pneumoniae type deOAc15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19344), Streptococcus pneumoniae type 23B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19349), Streptococcus pneumoniae type 20A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19347), Streptococcus pneumoniae type 31 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19351), Streptococcus pneumoniae type 16F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19345), Streptococcus pneumoniae type 11A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16715), Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB16711), Streptococcus pneumoniae type 15A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19343), Streptococcus pneumoniae type 24F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19350), Streptococcus pneumoniae type 9N capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB19342), Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10297)	••••••••••••			•••••••••• ••••••••
Prevention of	Invasive infection caused by streptococcus pneumoniae serotype 3		••••••••••••

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

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Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Apexxnar	Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 10a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 11a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 12f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 15b capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 µg/0.5ml) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 8 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 µg/0.5ml)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2022-06-06	Not applicable
Apexxnar	Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 10a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 11a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 12f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 15b capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 µg/0.5ml) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 8 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 µg/0.5ml)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2022-06-06	Not applicable
Apexxnar	Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 10a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 11a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 12f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 15b capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 µg/0.5ml) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 8 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 µg/0.5ml)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2022-06-06	Not applicable
Apexxnar	Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 10a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 11a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 12f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 15b capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 µg/0.5ml) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 8 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 µg/0.5ml)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2022-06-06	Not applicable
Apexxnar	Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 10a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 11a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 12f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 15b capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6a capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 µg/0.5ml) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 8 capsular polysaccharide antigen (2.2 µg/0.5ml) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 µg/0.5ml)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2022-06-06	Not applicable

Categories

Drug Categories

• Actively Acquired Immunity
• Inactivated Pneumococcal Vaccine

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

2VF3V7175U

CAS number

Not Available

References

General References

Not Available

External Links

PubChem Substance

347910480

RxNav

901628

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Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
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Not Available	Completed	Prevention	Infections, Rotavirus / Intestinal Bacteria Flora Disturbance / Streptococcal Pneumonia / Tetanus / Vaccine Reaction	1	somestatus	stop reason	just information to hide
4	Completed	Treatment	Asthma / Chronic Obstructive Pulmonary Disease (COPD) / Pneumococcal Infection	1	somestatus	stop reason	just information to hide
4	Recruiting	Basic Science	Coronavirus Disease 2019 (COVID‑19) / Lymphoma	1	somestatus	stop reason	just information to hide
4	Recruiting	Treatment	Acute Myeloid Leukemia / Non-Hodgkin's Lymphoma (NHL) / Streptococcus Pneumoniae / Vaccines	1	somestatus	stop reason	just information to hide
4	Terminated	Prevention	Pneumococcal Infection	1	somestatus	stop reason	just information to hide

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Pharmacoeconomics

Manufacturers

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Packagers

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Dosage Forms

Form	Route	Strength
Injection, solution	Intramuscular
Solution	Intramuscular
Liquid	Intramuscular; Subcutaneous
Injection, suspension	Intramuscular
Suspension	Intramuscular

Prices

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Patents

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Properties

State

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Experimental Properties

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Drug created at December 01, 2015 20:03 / Updated at August 13, 2021 20:47