Propiopromazine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Propiopromazine
- DrugBank Accession Number
- DB11540
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Vet approved
- Structure
- Weight
- Average: 340.49
Monoisotopic: 340.160934575 - Chemical Formula
- C20H24N2OS
- Synonyms
- Propionpromazine
- Propionylpromazine
- Propionylpromazone
- Propiopromazine
- External IDs
- BAY 188
- Bayer 188
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Propiopromazine is combined with 1,2-Benzodiazepine. Acebutolol The serum concentration of Acebutolol can be increased when it is combined with Propiopromazine. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Propiopromazine. Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Propiopromazine. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Propiopromazine. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Propiopromazine hydrochloride U0BND6SD2I 7681-67-6 ZFWVWZODBGTOIL-UHFFFAOYSA-N - International/Other Brands
- Combelen / Combilen
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazines
- Sub Class
- Phenothiazines
- Direct Parent
- Phenothiazines
- Alternative Parents
- Alkyldiarylamines / Diarylthioethers / Aryl alkyl ketones / Benzenoids / 1,4-thiazines / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl alkyl ketone / Aryl ketone / Aryl thioether / Azacycle / Benzenoid / Diarylthioether / Hydrocarbon derivative
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Y1BCT334I7
- CAS number
- 3568-24-9
- InChI Key
- ZQTVCQIJTREKSP-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H24N2OS/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20/h5-6,8-11,14H,4,7,12-13H2,1-3H3
- IUPAC Name
- 1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
- SMILES
- CCC(=O)C1=CC=C2SC3=C(C=CC=C3)N(CCCN(C)C)C2=C1
References
- General References
- Wheat JD: Penile paralysis in stallions given propiopromazine. J Am Vet Med Assoc. 1966 Feb 15;148(4):405-6. [Article]
- Olling M, Stephany RW, Rauws AG: The determination of propiopromazine in animal tissue. J Vet Pharmacol Ther. 1981 Dec;4(4):291-4. [Article]
- Haagsma N, Bathelt ER, Engelsma JW: Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues. J Chromatogr. 1988 Jan 29;436(1):73-9. [Article]
- Wronska D, Niezgoda J, Pierzchala K, Sechman A, Bobek S, Hamid AB: [Effect of phenothiazine derivative on adrenal cortex response of sheep to repeated emotional stress]. Endokrynol Pol. 1991;42(4):567-74. [Article]
- Hofman WF, Riegle GD: Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep. Am J Vet Res. 1977 Mar;38(3):403-6. [Article]
- Rauws AG: [Tranquilizers in the transport of slaughtering pigs: a problem of residues?]. Tijdschr Diergeneeskd. 1983 Sep 1;108(17):659-64. [Article]
- Garcia-Martinez D, Portilla-de Buen E, Leal C, Santillan P, Muniz J: The immediate response to severe shock in a canine model with a combination of hypertonic-hyperoncotic solution with naloxone. Shock. 2006 Oct;26(4):379-85. [Article]
- Patricolo M, Paolocci N, Zangari A, Antonica A, Rossi L, Magni F, Viola-Magni MP, Caione P, Lais A, Rivosecchi M: [Hepatic resection in the fetal rabbit. Histologic comparison of tissue regeneration in the fetus versus the adult]. Minerva Chir. 1996 Nov;51(11):971-7. [Article]
- External Links
- ChemSpider
- 22768
- BindingDB
- 50408509
- ChEMBL
- CHEMBL41169
- ZINC
- ZINC000000057465
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00538 mg/mL ALOGPS logP 4.74 ALOGPS logP 4.19 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 16.76 Chemaxon pKa (Strongest Basic) 9.11 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 23.55 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 103.98 m3·mol-1 Chemaxon Polarizability 39.5 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-0039000000-916df0ea7fb86bb82267 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-000i-0009000000-6ac0641b751d0607a6fb Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-9023000000-468eecd908dd56005de2 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-02br-0089000000-ba555f99957fc2b153f3 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-9041000000-0945455d257346c8ba8a Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0fbi-0490000000-e2717f716c9f8d38c2a7 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 198.1113496 predictedDarkChem Lite v0.1.0 [M-H]- 178.68086 predictedDeepCCS 1.0 (2019) [M+H]+ 198.6277496 predictedDarkChem Lite v0.1.0 [M+H]+ 181.03886 predictedDeepCCS 1.0 (2019) [M+Na]+ 198.5596496 predictedDarkChem Lite v0.1.0 [M+Na]+ 187.13202 predictedDeepCCS 1.0 (2019)
Drug created at February 26, 2016 17:39 / Updated at June 12, 2020 16:53