This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Carisbamate
- DrugBank Accession Number
- DB12338
- Background
Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Carisbamate (DB12338)
- Weight
- Average: 215.63
Monoisotopic: 215.0349209 - Chemical Formula
- C9H10ClNO3
- Synonyms
- Carisbamate
- External IDs
- JNJ-10234094
- RWJ-333369-000
- YKP-509
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Carisbamate is combined with 1,2-Benzodiazepine. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Carisbamate. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Carisbamate. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Carisbamate. Alfentanil The risk or severity of CNS depression can be increased when Alfentanil is combined with Carisbamate. - Food Interactions
- Not Available
Categories
- ATC Codes
- N03AX19 — Carisbamate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Halobenzenes
- Direct Parent
- Chlorobenzenes
- Alternative Parents
- Aryl chlorides / Carbamate esters / Secondary alcohols / Organonitrogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds / Aromatic alcohols
- Substituents
- Alcohol / Aromatic alcohol / Aromatic homomonocyclic compound / Aryl chloride / Aryl halide / Carbamic acid ester / Carbonyl group / Chlorobenzene / Hydrocarbon derivative / Organic nitrogen compound
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- P7725I9V3Z
- CAS number
- 194085-75-1
- InChI Key
- OLBWFRRUHYQABZ-MRVPVSSYSA-N
- InChI
- InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
- IUPAC Name
- (2S)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
- SMILES
- NC(=O)OC[C@@H](O)C1=CC=CC=C1Cl
References
- General References
- Not Available
- External Links
- PubChem Compound
- 6918474
- PubChem Substance
- 347828597
- ChemSpider
- 5293671
- ChEBI
- 135966
- ChEMBL
- CHEMBL2087003
- ZINC
- ZINC000030691363
- Wikipedia
- Carisbamate
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Completed Treatment Complex Partial Seizure Disorder / Epilepsy / Focal Impaired Awareness Seizures / Partial Epilepsy 1 somestatus stop reason just information to hide 3 Completed Treatment Epilepsy, Partial, Motor / Focal Impaired Awareness Seizures / Partial Seizures, Simple 2 somestatus stop reason just information to hide 3 Recruiting Treatment Lennox-Gastaut Syndrome / Seizures 1 somestatus stop reason just information to hide 3 Terminated Treatment Epilepsy / Seizures 1 somestatus stop reason just information to hide 2 Completed Treatment Diabetic Mononeuropathy / Diabetic Polyneuropathy / Neuralgia, Diabetic / Painful Diabetic Neuropathy (PDN) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.15 mg/mL ALOGPS logP 0.94 ALOGPS logP 1.29 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 13.43 Chemaxon pKa (Strongest Basic) -3.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 72.55 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 51.47 m3·mol-1 Chemaxon Polarizability 20.38 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-5900000000-5243dde1463d8e4c28cf Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-052o-0910000000-76c9c7986e84cf3bf5ec Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9300000000-1cecd4f706b544ddb7bf Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03dl-0900000000-b12906775364a5112537 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9000000000-9b301a5d281a74c1bc83 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9000000000-7cf6092e14287c9b9ac2 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-08j3-1900000000-546a271c83b3a7e66d9b Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 138.69902 predictedDeepCCS 1.0 (2019) [M+H]+ 141.09459 predictedDeepCCS 1.0 (2019) [M+Na]+ 147.0717 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 22:00 / Updated at February 21, 2021 18:53