This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Thiazinam
- DrugBank Accession Number
- DB13420
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Thiazinam (DB13420)
- Weight
- Average: 299.46
Monoisotopic: 299.157646343 - Chemical Formula
- C18H23N2S
- Synonyms
- Thiazinamium
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
Pathway Category Thiazinamium H1-Antihistamine Action Drug action - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Thiazinam. Acebutolol The serum concentration of Acebutolol can be increased when it is combined with Thiazinam. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Thiazinam. Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Thiazinam. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Thiazinam. - Food Interactions
- Not Available
Categories
- ATC Codes
- R06AD06 — Thiazinam
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazines
- Sub Class
- Phenothiazines
- Direct Parent
- Phenothiazines
- Alternative Parents
- Alkyldiarylamines / Diarylthioethers / Benzenoids / 1,4-thiazines / Tetraalkylammonium salts / Azacyclic compounds / Organopnictogen compounds / Organic salts / Hydrocarbon derivatives / Organic cations
- Substituents
- Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Diarylthioether / Hydrocarbon derivative / Organic cation / Organic nitrogen compound
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 666W2P28N2
- CAS number
- 2338-21-8
- InChI Key
- CDXCCYNINPIWGE-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H23N2S/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19/h5-12,14H,13H2,1-4H3/q+1
- IUPAC Name
- trimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]azanium
- SMILES
- CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)[N+](C)(C)C
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0240235
- ChemSpider
- 5794
- ChEBI
- 135268
- ChEMBL
- CHEMBL2111135
- Wikipedia
- Thiazinamium_metilsulfate
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000171 mg/mL ALOGPS logP 0.26 ALOGPS logP 0.13 Chemaxon logS -6.3 ALOGPS pKa (Strongest Basic) -4.7 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 3.24 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 104.42 m3·mol-1 Chemaxon Polarizability 34.38 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-001r-9040000000-32726e2129d72228ab00 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 167.79904 predictedDeepCCS 1.0 (2019) [M+H]+ 170.15709 predictedDeepCCS 1.0 (2019) [M+Na]+ 177.37132 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:41 / Updated at June 12, 2020 16:53