5-hydroxytryptamine receptor 1D
Details
- Name
- 5-hydroxytryptamine receptor 1D
- Synonyms
- 5-HT-1D
- 5-HT-1D-alpha
- HTR1DA
- HTRL
- Serotonin 1D alpha receptor
- Serotonin receptor 1D
- Gene Name
- HTR1D
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010458|5-hydroxytryptamine receptor 1D MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN EEFRQAFQKIVPFRKAS
- Number of residues
- 377
- Molecular Weight
- 41906.38
- Theoretical pI
- 8.85
- GO Classification
- Functionsserotonin binding / serotonin receptor activityProcessesadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / intestine smooth muscle contraction / regulation of behavior / regulation of locomotion / response to toxic substance / serotonin receptor signaling pathway / synaptic transmission / vasoconstrictionComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Serotonin receptor activity
- Specific Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 39-64 76-98 113-134 155-176 195-217 303-326 336-360
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010459|5-hydroxytryptamine receptor 1D (HTR1D) ATGTCCCCACTGAACCAGTCAGCAGAAGGCCTTCCCCAGGAGGCCTCCAACAGATCCCTG AATGCCACAGAAACCTCAGAGGCTTGGGATCCCAGGACCCTCCAGGCGCTCAAGATCTCC CTTGCCGTGGTCCTTTCCGTCATCACACTGGCCACAGTCCTCTCCAATGCCTTTGTACTC ACCACCATCTTACTCACCAGGAAGCTCCACACCCCTGCCAACTACCTGATTGGCTCCCTG GCCACCACCGACCTCTTGGTTTCCATCTTGGTAATGCCCATCAGCATCGCCTATACCATC ACCCACACCTGGAACTTTGGCCAAATCTTGTGTGACATCTGGCTGTCCTCTGACATCACG TGCTGCACAGCCTCCATCCTGCATCTCTGTGTCATTGCTCTGGACAGGTACTGGGCAATC ACAGATGCCCTGGAATACAGTAAACGCAGGACGGCTGGCCACGCGGCCACCATGATCGCC ATTGTCTGGGCCATCTCCATCTGCATCTCCATCCCCCCGCTCTTCTGGCGGCAGGCCAAG GCCCAGGAGGAGATGTCGGACTGTCTGGTGAACACCTCTCAGATCTCCTACACCATCTAC TCCACCTGTGGGGCCTTCTACATTCCCTCGGTGTTGCTCATCATCCTATATGGCCGGATC TACCGGGCTGCCCGGAACCGCATCCTGAATCCACCCTCACTCTATGGGAAGCGCTTCACC ACGGCCCACCTCATCACAGGCTCTGCCGGGTCCTCGCTCTGCTCGCTCAACTCCAGCCTC CATGAGGGGCACTCGCACTCGGCTGGCTCCCCTCTCTTTTTCAACCACGTGAAAATCAAG CTTGCTGACAGTGCCCTGGAACGCAAGAGGATTTCTGCTGCTCGAGAAAGGAAAGCCACT AAAATCCTGGGCATCATTCTGGGGGCCTTTATCATCTGCTGGCTGCCCTTCTTCGTGGTG TCTCTGGTCCTCCCCATCTGCCGGGACTCCTGCTGGATCCACCCGGCGCTCTTTGACTTC TTCACCTGGCTAGGCTATTTAAACTCCCTCATCAATCCAATAATCTACACTGTGTTTAAT GAAGAGTTTCGGCAAGCTTTTCAGAAAATTGTCCCTTTCCGGAAGGCCTCCTAG
- Chromosome Location
- 1
- Locus
- 1p36.3-p34.3
- External Identifiers
Resource Link UniProtKB ID P28221 UniProtKB Entry Name 5HT1D_HUMAN GenBank Protein ID 177772 GenBank Gene ID M89955 GenAtlas ID HTR1D HGNC ID HGNC:5289 - General References
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- Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00216 Eletriptan approved, investigational yes agonist Details DB00315 Zolmitriptan approved, investigational yes agonist Details DB00320 Dihydroergotamine approved, investigational yes agonist Details DB00669 Sumatriptan approved, investigational yes agonist Details DB00918 Almotriptan approved, investigational unknown agonist Details DB00952 Naratriptan approved, investigational yes agonist Details DB00953 Rizatriptan approved yes agonist Details DB00998 Frovatriptan approved, investigational yes agonist Details DB00246 Ziprasidone approved yes antagonist Details DB00696 Ergotamine approved yes agonist Details DB06096 NXN-188 investigational unknown Details DB01186 Pergolide approved, investigational, vet_approved, withdrawn unknown agonist Details DB01200 Bromocriptine approved, investigational, withdrawn unknown agonist Details DB00589 Lisuride approved, investigational unknown agonist Details DB00248 Cabergoline approved unknown agonist Details DB00714 Apomorphine approved, investigational unknown agonist Details DB01267 Paliperidone approved unknown antagonist Details DB01224 Quetiapine approved unknown ligand Details DB00363 Clozapine approved unknown antagonist Details DB01238 Aripiprazole approved, investigational unknown antagonistligand Details DB01392 Yohimbine approved, investigational, vet_approved unknown partial agonist Details DB00408 Loxapine approved unknown binder Details DB00726 Trimipramine approved unknown binder Details DB00321 Amitriptyline approved unknown binder Details DB04948 Lofexidine approved, investigational no agonist Details DB14185 Aripiprazole lauroxil approved, investigational unknown Details DB00734 Risperidone approved, investigational unknown antagonist Details DB00574 Fenfluramine approved, illicit, investigational, withdrawn yes agonist Details DB00935 Oxymetazoline approved, investigational unknown agonist Details DB13025 Tiapride investigational yes antagonist Details DB09304 Setiptiline experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB12141 Gilteritinib approved, investigational no inhibitor Details DB00715 Paroxetine approved, investigational unknown Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn yes inhibitor Details DB01221 Ketamine approved, vet_approved unknown antagonist Details DB00334 Olanzapine approved, investigational unknown inhibitor Details DB12540 Lecozotan investigational unknown regulator Details