Reaction: Bendamustine to 1 product

Reaction
Bendamustine
DB06769
N-desmethyl-bendamustine (Bendamustine metabolite M4)
DBMET01422
Reaction type
dealkylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Darwish M, Bond M, Hellriegel E, Robertson P Jr, Chovan JP: Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54. doi: 10.1007/s00280-015-2727-6. Epub 2015 Apr 1. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A2Not AvailableNot Availableconfirmed